Human Anti-HBEGF Recombinant Antibody (clone KM3966) (CAT#: VS-0624-FY12)

• Immunogen
• Recombinant human HB-EGF

• Host Species
• Human

• Type
• Human IgG1

• Specificity
• Human HBEGF

• Species Reactivity
• Human

• Clone
• KM3966

• Applications
• Neutralization, ADCC, Flow Cytometry

• Related Disease
• Diphtheria and Perinatal Necrotizing Enterocolitis

• Clonality
• Monoclonal Antibody

• Purification
• Protein A purified

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Neutralization: 30 μg/mL

• Alternative Names
• Heparin Binding EGF Like Growth Factor; Diphtheria Toxin Receptor (Heparin-Binding Epidermal Growth Factor-Like Growth Factor); Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor); Heparin-Binding Epidermal Growth Factor; HEGFL; DTR

• Gene ID
• 1839

• UniProt ID
• Q99075

• Long Name
• Heparin Binding EGF Like Growth Factor

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Several N-termini have been identified by direct sequencing.
  The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
  (Q99075-HBEGF_HUMAN)
  O-glycosylated with core 1 or possibly core 8 glycans.
  Thr-47 is a minor glycosylation site compared to Thr-44.
  (Q99075-HBEGF_HUMAN)
  Glycosylation at Thr37, Ser38, Thr44, Ser46, Thr47, Thr75, Ser77, Ser78, and Thr85 (NX_Q99075 [NX_Q99075-1])
  Modification sites at PhosphoSitePlus (Q99075)
  Glycosylation from GlyConnect HBEGF_HUMAN (809)
  Glycosylation from GlyGen (Q99075) 10 sites, 7 O-linked glycans (9 sites)

• Protein Refseq
• NP_001936.1

• Function
• May be involved in macrophage-mediated cellular proliferation.
  It is mitogenic for fibroblasts, but not endothelial cells.
  It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.
  Also acts as a diphtheria toxin receptor.

Isotype Control

• MOB-0402ZL
• Human IgG1, kappa - Isotype Control Antibody

• MOB-173CQ
• Human IgG1, lambda Isotype Control Antibody

Secondary Antibody

• 2RD-A1571-YJ
• Rabbit Anti-Human IgG1 Secondary antibody (Clone RM117)

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