Human Anti-HIV-1 gp41 Recombinant Antibody (clone A12) (CAT#: MRO-4145CQ)
This product is a recombinant human anti-HIV-1 monoclonal antibody. A12 specifically binds to gp41.
Specific Inquiry
Inhib
Figure 1 NB-2 inhibits 6-HB formation in a dose-dependent manner, as assessed by N-PAGE.
NB-2 at different concentration was mixed with N36 at 37 °C for 30 min before
addition of C34.
Yu, F., Lu, L., Du, L., Zhu, X., Debnath, A. K., & Jiang, S. (2013). Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket. Viruses, 5(1), 127-149.
Neut
Figure 2 Resistance of CD4bs sdAb A12 to heat inactivation and to changes in pH shown as % of untreated neutralizing activity.
It is not clear why the higher temperature of 80 °C retained greater activity than 60 °C and 70 °C.
Weiss, R. A., & Verrips, C. T. (2019). sdAbs that neutralize HIV. Vaccines, 7(3), 77.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Recognizes HIV-1 gp41
- Species Reactivity
- HIV-1
- Clone
- A12
- Applications
- Inhib, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Inhibition, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone A12"
See other products for "HIV-1 gp41"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-486-S(P) | Recombinant Anti-HIV-1 gp41 Antibody scFv Fragment | FC, WB, FuncS | scFv |
| PSBC-331 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-331) | Neut | Mouse scFv |
| PSBC-332 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8v4-5R+100cF); scFv Fragment | Neut | Human scFv |
| PSBC-334 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-334) | ELISA, Neut | Mouse scFv |
| PSBC-335 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-335) | ELISA, Neut | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-068 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1583) | Neut, FC | Mouse IgG2a, κ |
| PABW-068 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone D5) | WB, ELISA | Human IgG |
| PABC-069 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HK20) | WB, ELISA, Neut | Human IgG |
| PABL-558 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8066) | WB, Neut | Human IgG |
| PABL-559 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 11f10) | WB, ELISA, FuncS | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-068 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1583); Fab Fragment | Neut | Mouse Fab |
| PFBW-068 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone D5); Fab Fragment | WB, ELISA | Human Fab |
| PFBC-069 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HK20); Fab Fragment | Neut, ELISA | Human Fab |
| MRO-4074CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone A9); Fab Fragment | ELISA | Human Fab |
| MRO-4075CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone D11); Fab Fragment | ELISA | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-025LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG3) | ELISA | Human antibody |
| MRO-026LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) | ELISA | Human antibody |
| MRO-040LC | Anti-HIV-1 gp41 Recombinant Antibody (M66.6) | ELISA | Human antibody |
| MRO-074LC | Anti-HIV-1 gp41 Recombinant Antibody (W) | ELISA | Human antibody |
| MRO-077LC | Anti-HIV-1 gp41 Recombinant Antibody (3D6) | ELISA | Human antibody |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for MRO-4145CQ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.