Mouse Anti-HLA-DRA Recombinant Antibody (clone K8-355) (CAT#: VS-0724-XY77)
The antibody K8-355 (murine IgG1/ kappa) is a recombinant mouse antibody targeting the HLA-DRA (Major histocompatibility complex, class II, DR alpha), which plays a central role in the immune system and response by presenting peptides derived from extracellular proteins. This antibody has a pan-HLA-DR reactivity. it binds to all cells that express HLA-DR in spite of the polymorphic nature of the molecules.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
Figure 3 High expression in lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
Figure 4 Tonsil
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
Specifications
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG1 kappa
- Specificity
- HLA-DRA
- Species Reactivity
- Human
- Clone
- K8-355
- Applications
- ELISA, FC
- Related Disease
- Graham Little-Piccardi-Lassueur Syndrome; Autoimmune Hepatitis
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target
- Alternative Names
- HLA-DRA1
- Gene ID
- 3122
- UniProt ID
- P01903
- Cellular Localization
- Cell membrane; Endoplasmic reticulum membrane
- Post Translation Modifications
- Glycosylation at Asn103 and Asn143.
Ubiquitination at Lys244.
- Protein Refseq
- NP_061984.2
- Function
- An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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