Mouse Anti-HLA-DRA Recombinant Antibody (clone K8-355)
CAT#: VS-0724-XY77
The antibody K8-355 (murine IgG1/ kappa) is a recombinant mouse antibody targeting the HLA-DRA (Major histocompatibility complex, class II, DR alpha), which plays a central role in the immune system and response by presenting peptides derived from extracellular proteins. This antibody has a pan-HLA-DR reactivity. it binds to all cells that express HLA-DR in spite of the polymorphic nature of the molecules.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
Normal Tissue
Figure 3 High expression in lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
Normal Tissue
Figure 4 Tonsil
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
❮
❯
Specifications
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG1 kappa
- Specificity
- HLA-DRA
- Species Reactivity
- Human
- Clone
- K8-355
- Applications
- ELISA, FC
- Related Disease
- Graham Little-Piccardi-Lassueur Syndrome; Autoimmune Hepatitis
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95%, determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Target
- Alternative Names
- HLA-DRA1
- Gene ID
- 3122
- UniProt ID
- P01903
- Cellular Localization
- Cell membrane; Endoplasmic reticulum membrane
- Post Translation Modifications
- Glycosylation at Asn103 and Asn143.
Ubiquitination at Lys244.
- Protein Refseq
- NP_061984.2
- Function
- An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0724-XY77. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "HLA-DRA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC703 | I-Ab/Human Eα (ASFEAQGALANIAVDKA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1622 | Rabbit Anti-HLA-DRA Recombinant Antibody (clone DS1622AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3350 | PE-DRB1*04:04/Human HLA-DRA (ANIAVDKANLEIMTKR) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-037CN | Human Anti-HLA-DRA Recombinant Antibody (clone HD4) | ELISA, WB, FC, FuncS | Human IgG1 |
| NS-038CN | Human Anti-HLA-DRA Recombinant Antibody (clone HD8) | ELISA, WB, FC, FuncS | Human IgG2 |
| NS-037CN-F(E) | Human Anti-HLA-DRA Recombinant Antibody (clone HD4); Fab Fragment | ELISA, WB, FC | Human Fab |
| NS-038CN-F(E) | Human Anti-HLA-DRA Recombinant Antibody (clone HD8); Fab Fragment | ELISA, WB, FC | Human Fab |
| NS-037CN-S(P) | Human Anti-HLA-DRA Recombinant Antibody (clone HD4); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1936-CN | Rabbit Anti-HLA-DRA Polyclonal Antibody (MRO-1936-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1937-CN | Rabbit Anti-HLA-DRA Polyclonal Antibody (MRO-1937-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0025-YJ | Human Anti-HLA-DRA Recombinant Antibody (clone ChDN1924) | Apop, IF | Chimeric (mouse/human) IgG2, κ |
| VS-0724-XY76 | Human Anti-HLA-DRA Recombinant Antibody (clone c44H10) | ELISA, BLI | Human IgG |
| VS-0724-XY78 | Monkey Anti-HLA-DRA Recombinant Antibody (clone MS-GPC-8-10-57) | ELISA, BLI, Neut | Monkey IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0025-YJ-S(P) | Mouse Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); scFv Fragment | Apop, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0025-YJ-F(E) | Human Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); Fab Fragment | Apop, IF | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY125 | AbPlus™ Anti-HLA-DRA Magnetic Beads (Bra30) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY250 | Mouse Anti-NHP HLA-DRA Recombinant Antibody (clone IPO-10) | IF, FC | Mouse IgG3, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC442 | Recombinant Anti-HLA-DRA Vesicular Antibody, EV Displayed (VS-0425-YC442) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: ELISA, FC, WB, Block
Application: SPR, Inhib, FuncS
Application: ELISA, Inhib, FC, Neut
Application: IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, FuncS, Neut, IF, WB, EM, Inhib, IHC
Application: ELISA
-3.jpg)
Application: IB, FC, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
