Anti-IFNAR1 Antibody Prodrug, Protease Activated (S3A5)
CAT#: VS-1025-YC155
The Anti-IFNAR1 Antibody Prodrug, Protease Activated (S3A5) is an antibody prodrug comprised of a recombinant human antibody targeting human IFNAR1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IFNAR1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IFNAR1 effectively. IFNAR1 is a subunit of the Type I interferon receptor complex. Loss-of-function mutations in IFNAR1 are a mechanism of immune evasion in some cancers, preventing tumor cells from responding to interferon-mediated immune destruction and making them resistant to specific immunotherapies.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_A_4_6.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_A_9_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142166-IFNAR1
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Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human IFNAR1
- Target
- IFNAR1
- Species Reactivity
- Human
- Isotype
- IgG
- Clone
- S3A5
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
- Alternative Names
- AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
- Gene ID
- 3454
- UniProt ID
- P17181
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone S3A5"
- CAT
- Product Name
See other products for "IFNAR1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1305z | Mouse Anti-IFNAR1 Recombinant Antibody (MOB-1305z) | ELISA, WB, IP, IF, IHC, FC | Mouse IgG1, κ |
| PABL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546) | WB, ELISA, FuncS | Human IgG |
| MOB-0994MZ | Recombinant Mouse Anti-Human IFNAR1 Antibody (clone NN0447-9I57) | FC | Mouse antibody |
| HPAB-0158-CN | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5) | FC | Human IgG |
| HPAB-0159-CN | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1305z-F(E) | Recombinant Anti-Human IFNAR1 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| PFBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0158-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5); Fab Fragment | ELISA | Human Fab |
| HPAB-0159-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4); Fab Fragment | ELISA | Human Fab |
| HPAB-0160-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1305z-S(P) | Recombinant Anti-Human IFNAR1 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| PSBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0158-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5); scFv Fragment | ELISA | Human scFv |
| HPAB-0159-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4); scFv Fragment | ELISA | Human scFv |
| HPAB-0160-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-130CT | Anti-Human IFNAR-1 Recombinant Antibody (64G12) | WB, IF, FuncS | |
| TAB-130CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (64G12) | ELISA, FC | |
| TAB-130CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (64G12) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-131CT | Anti-Human IFNAR-1 Recombinant Antibody (CPI-1697) | ELISA, FC | Humanized antibody |
| TAB-131CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
| TAB-131CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-976CQ | Mouse Anti-Ifnar1 Recombinant Antibody (clone MAR1-5A3) | FC, Neut, IP, WB, B | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1740 | Rabbit Anti-IFNAR1 Recombinant Antibody (clone DS1740AB) | WB, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-722 | Afuco™ Anti-IFNAR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-722) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1020 | AbPlus™ Anti-IFNAR1 Magnetic Beads (VS-0724-YC1020) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY117 | Mouse Anti-IFNAR1 (clone 64G12) scFv-Fc Chimera | Block | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC253 | Recombinant Anti-IFNAR1 Vesicular Antibody, EV Displayed (VS-0425-YC253) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3409 | Anti-IFNAR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3410 | Anti-Mouse IFNAR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC2 | SmartAb™ Recombinant Anti-IFNAR1 pH-dependent Antibody (Clone MEDI546) | WB, ELISA | Human IgG |
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