Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546) (CAT#: PABL-228)
Recombinant Antagonist Human Antibody (MEDI546) is capable of binding to IFNAR1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IFNAR1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IFNAR1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Mean (±SD) serum MEDI-546 concentration.
A. Single IV Administration; B. Multiple IV Administrations. LLOQ, lower limit of quantitation; SD, standard deviation. Mean data below LLOQ are not plotted.
Goldberg, A., Geppert, T., Schiopu, E., Frech, T., Hsu, V., Simms, R. W.,... & Wang, B. (2014). Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study. Arthritis research & therapy,16(1), R57.
Specifications
- Immunogen
- Human interferon (alpha, beta and omega) receptor 1
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human IFNAR1
- Species Reactivity
- Human
- Clone
- MEDI546
- Applications
- WB, ELISA, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Immunofluorescence and Inhibition. For details, refer to Published Data.
Target
- Alternative Names
- IFNAR1; interferon (alpha; beta and omega) receptor 1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain
- Gene ID
- 3454
- UniProt ID
- P17181
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0158-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5); scFv Fragment | ELISA | Human scFv |
| HPAB-0159-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4); scFv Fragment | ELISA | Human scFv |
| HPAB-0160-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1); scFv Fragment | ELISA | Human scFv |
| HPAB-0161-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-2); scFv Fragment | ELISA | Human scFv |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-228, RRID: AB_3111641)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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