SmartAb™ Recombinant Anti-IFNAR1 pH-dependent Antibody (Clone MEDI546)
CAT#: VS-0825-YC2
The anti-IFNAR1 pH-dependent antibody (clone MEDI546) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human interferon (alpha, beta, and omega) receptor 1 (IFNAR1). By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for IFNAR1 under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from IFNAR1 at pH 6.0. This pH-sensitive antibody retains its binding affinity for IFNAR1 on tumor cells while exhibiting negligible binding to the same receptor on normal cells at physiological pH. IFNAR1 is a type I membrane protein that, in conjunction with IFNAR2, forms the receptor complex for Type I interferons. This receptor plays a critical role in immune function by initiating the JAK-STAT signaling pathway, which mediates a robust antiviral and immune response.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_A_4_6.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29226/75714_A_9_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142166-IFNAR1
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human interferon (alpha, beta and omega) receptor 1
- Species Reactivity
- Human
- Clone
- MEDI546
- Applications
- WB, ELISA
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- IFNAR1; interferon (alpha; beta and omega) receptor 1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain
- Gene ID
- 3454
- UniProt ID
- P17181
- Long Name
- Interferon Alpha And Beta Receptor Subunit 1
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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