Mouse Anti-IFNAR1 (clone 64G12) scFv-Fc Chimera (CAT#: VS-0425-FY117)

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• Human IFNAR1

• Species Reactivity
• Human

• Clone
• 64G12

• Applications
• Blocking

• Related Disease
• Immunodeficiency 106 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interferon Alpha And Beta Receptor Subunit 1

• Gene ID
• 3454

• UniProt ID
• P17181

• Long Name
• Interferon Alpha And Beta Receptor Subunit 1

• Sequence Similarities
• Belongs to the type II cytokine receptor family.

• Cellular Localization
• Cell membrane, Endosome, Lysosome, Membrane

• Post Translation Modifications
• Ubiquitinated, leading to its internalization and degradation.
  Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation.
  The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.
  Phosphorylated on tyrosine residues in response to interferon-binding: phosphorylation by TYK2 tyrosine kinase creates docking sites for STAT proteins.
  Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination.
  Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

• Protein Refseq
• NP_000620.2

• Function
• Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa).
  Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response.
  Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another.
  The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors.
  STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.
  Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

• TAB-130CT
• Anti-Human IFNAR-1 Recombinant Antibody (64G12)

• TAB-130CT-S(P)
• Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (64G12)

• TAB-130CT-F(E)
• Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (64G12)

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