Provided are anti-IgE antibodies that bind to the M1′ segment of a human IgE. The antibody can be used in treating and preventing IgE-mediated disorders, as well as kits comprising the anti-IgE antibodies.
Figure 1 Identification of schlstosomulum antigen reactlng wlth IgE.
Immune complexes were absorbed on protein A-Sepharoseand were then analyzed.
Verwaerde, C., Joseph, M., Capron, M., Pierce, R. J., Damonneville, M., Velge, F., ... & Capron, A. (1987). Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. The Journal of Immunology, 138(12), 4441-4446.
Figure 2 Killing of S. mansoni schistosomula by B48-14 IgE In the presence of various effector cells.
Schistosomula were incubated with effector cells.
Verwaerde, C., Joseph, M., Capron, M., Pierce, R. J., Damonneville, M., Velge, F., ... & Capron, A. (1987). Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. The Journal of Immunology, 138(12), 4441-4446.
Figure 3 Detection of anti-DNP IgE antibody by ELISA.
The ordinate indicates the optical density (OD: 492 nm) of ELISA readings after subtraction of the background.
Verwaerde, C., Joseph, M., Capron, M., Pierce, R. J., Damonneville, M., Velge, F., ... & Capron, A. (1987). Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. The Journal of Immunology, 138(12), 4441-4446.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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