Anti-IL10 Antibody Prodrug, Protease Activated (VS-1025-YC207)
CAT#: VS-1025-YC207
The Anti-IL10 Antibody Prodrug, Protease Activated (VS-1025-YC207) is an antibody prodrug comprised of a recombinant human antibody targeting human IL10, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IL10 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IL10 effectively. IL10 (Interleukin 10) is an immunosuppressive cytokine often secreted at high levels by the tumor microenvironment. Its primary role is to suppress the function of effector T-cells and NK cells, promoting immune tolerance and aiding the tumor in immune evasion.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HMC-1, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136634-IL10
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human, Mouse and Cynomolgus IL10
- Target
- IL10
- Species Reactivity
- Human, Mouse, Cynomolgus
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
- Alternative Names
- CSIF; TGIF; GVHDS; IL-10; IL10A
- Gene ID
- 3586
- UniProt ID
- P22301
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Systemic Lupus Erythematosus
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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