Anti-IL15 (clone 146B7) Recombinant Antibody Coupled Liposome (VS-1024-FY19)
CAT#: VS-1024-FY19
Anti-IL-15 conjugated liposomes may exhibit cytotoxic effects on T cell lines, supporting their potential application in anti-tumor therapy. Some studies have shown that IL-15 agonists have unique effects in inhibiting tumor growth and preventing metastasis, while also activating NK cells and CD8 memory T cells, further influencing T cell function. It is recommended that you review relevant research for more detailed information.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/785_B10_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/783_B10_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_B_8_5.jpg
Normal Tissue
Figure 6 Lung
Macrophages
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_1_4.jpg
Normal Tissue
Figure 7 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_8_3.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_6_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
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More Infomation
Specifications
- Potential Clinical Applications
- Potentially kill T cell lines (e.g. CCRFCEM)
Product Composition
- Clone
- 146B7
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant human monoclonal antibody meticulously engineered to specifically target interleukin-15 (IL-15). IL-15 is a crucial cytokine involved in the regulation of immune responses, particularly in promoting the proliferation and survival of T cells and natural killer (NK) cells. By binding selectively to IL-15, this monoclonal antibody can modulate various immune processes, making it a valuable tool for both research and therapeutic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL15
- Introduction
- The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
- Alternative Names
- Interleukin 15
- Full Name
- Interleukin 15
- Gene ID
- 3600
- UniProt ID
- P40933
- Sequence Similarities
- Belongs to the IL-15/IL-21 family.
- Cellular Localization
- Cytoplasm, Nucleus, Secreted
- Post Translation Modifications
- Glycosylation at Asn127 (NX_P40933 [NX_P40933-1])
Modification sites at PhosphoSitePlus (P40933)
Glycosylation from GlyGen (P40933) 1 site
- Protein Refseq
- NP_000576.1; NP_751915.1
- Function
- Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770).
Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.
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Related Diseases
Rheumatoid Arthritis
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 146B7"
- CAT
- Product Name
See other products for "IL15"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-398CL | Human Anti-IL15 Recombinant Antibody (TAB-398CL) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-382CL | Afuco™ Anti-IL15 Recombinant Antibody (AFC-382CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-081 | Human Anti-IL15 Recombinant Antibody (clone DISC0280); Fab Fragment | Neut | Human Fab |
| HPAB-S0072-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 4H10); Fab Fragment | ELISA | Human Fab |
| HPAB-S0073-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 1H3); Fab Fragment | ELISA | Human Fab |
| HPAB-S0074-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 3C1); Fab Fragment | ELISA | Human Fab |
| HPAB-S0075-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 8C5); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-081 | Human Anti-IL15 Recombinant Antibody (clone DISC0280); scFv Fragment | Neut | Human scFv |
| HPAB-S0072-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 4H10); scFv Fragment | ELISA | Human scFv |
| HPAB-S0073-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 1H3); scFv Fragment | ELISA | Human scFv |
| HPAB-S0074-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 3C1); scFv Fragment | ELISA | Human scFv |
| HPAB-S0075-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 8C5); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0234CL | Human Anti-IL15 Recombinant Antibody (TAB-0234CL) | ELISA | Human IgG |
| TAB-0235CL | Human Anti-IL15 Recombinant Antibody (TAB-0235CL) | ELISA | Human IgG |
| TAB-0236CL | Human Anti-IL15 Recombinant Antibody (TAB-0236CL) | ELISA | Human IgG |
| TAB-0237CL | Human Anti-IL15 Recombinant Antibody (TAB-0237CL) | ELISA | Human IgG |
| TAB-0238CL | Human Anti-IL15 Recombinant Antibody (TAB-0238CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-075ZJ | Anti-Human IL-15 Recombinant Antibody (DISC0100) | ELISA | Human antibody |
| TAB-075ZJ-S(P) | Anti-Human IL-15 Recombinant Antibody scFv Fragment (DISC0100) | ELISA | Human antibody |
| TAB-076ZJ-S(P) | Anti-Human IL-15 Recombinant Antibody scFv Fragment (DISC0280) | ELISA | Human antibody |
| TAB-075ZJ-F(E) | Anti-Human IL-15 Recombinant Antibody Fab Fragment (DISC0100) | ELISA | Human antibody |
| TAB-076ZJ-F(E) | Anti-Human IL-15 Recombinant Antibody Fab Fragment (DISC0280) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-198LC | Recombinant Anti-Human IL15 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-198LC-1 | Recombinant Anti-Human IL15 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1191CQ | Mouse Anti-IL15 Recombinant Antibody (NEUT-1191CQ) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1192CQ | Mouse Anti-IL15 Recombinant Antibody (clone MM0368-13S34) | WB, Neut | Mouse IgG1 |
| NEUT-1193CQ | Rat Anti-IL15 Recombinant Antibody (clone AIO.3) | Neut | Rat IgG2a, κ |
| NEUT-1195CQ | Mouse Anti-IL15 Recombinant Antibody (clone CBL096) | Neut, WB | Mouse IgG1 |
| NEUT-1196CQ | Mouse Anti-IL15 Recombinant Antibody (clone CBL457) | WB, CyTOF, ICFC, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1194CQ | Mouse Anti-IL15 Recombinant Antibody (clone B-E29) | Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1792 | Rabbit Anti-IL15 Recombinant Antibody (clone DS1792AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0238-YC | Human Anti-IL15 Recombinant Antibody (HPAB-0238-YC) | ELISA, FC, Inhib, FuncS | Human IgG |
| HPAB-S0072-YC | Human Anti-IL15 Recombinant Antibody (clone 4H10) | ELISA | Human IgG |
| HPAB-S0073-YC | Human Anti-IL15 Recombinant Antibody (clone 1H3) | ELISA | Human IgG |
| HPAB-S0074-YC | Human Anti-IL15 Recombinant Antibody (clone 3C1) | ELISA | Human IgG |
| HPAB-S0075-YC | Human Anti-IL15 Recombinant Antibody (clone 8C5) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY276 | Mouse Anti-NHP IL15 Recombinant Antibody (clone 34505) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY124 | Human Anti-IL15 (clone 146B7) scFv-Fc Chimera | ELISA, FC, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3487 | Anti-IL15 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC166 | Recombinant Anti-IL15 Eliminating Antibody, pH-Sensitive (VS-0625-YC166) | Antigen-Sweeping In Vivo. | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC174 | SmartAb™ Recombinant Anti-IL15 pH-dependent Antibody (VS-0825-YC174) | ELISA, FC, Inhib | Human IgG |
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