Anti-IL15 (clone 146B7) Recombinant Antibody Coupled Liposome (VS-1024-FY19) (CAT#: VS-1024-FY19)

• Potential Clinical Applications
• Potentially kill T cell lines (e.g. CCRFCEM)

• Clone
• 146B7

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant human monoclonal antibody meticulously engineered to specifically target interleukin-15 (IL-15). IL-15 is a crucial cytokine involved in the regulation of immune responses, particularly in promoting the proliferation and survival of T cells and natural killer (NK) cells. By binding selectively to IL-15, this monoclonal antibody can modulate various immune processes, making it a valuable tool for both research and therapeutic applications.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IL15

• Introduction
• The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

• Alternative Names
• Interleukin 15

• Full Name
• Interleukin 15

• Gene ID
• 3600

• UniProt ID
• P40933

• Sequence Similarities
• Belongs to the IL-15/IL-21 family.

• Cellular Localization
• Cytoplasm, Nucleus, Secreted

• Post Translation Modifications
• Glycosylation at Asn127 (NX_P40933 [NX_P40933-1])
  Modification sites at PhosphoSitePlus (P40933)
  Glycosylation from GlyGen (P40933) 1 site

• Protein Refseq
• NP_000576.1; NP_751915.1

• Function
• Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770).
  Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.

• VS-0325-FY124
• Human Anti-IL15 (clone 146B7) scFv-Fc Chimera

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