Human Anti-IL15 (clone 146B7) scFv-Fc Chimera
CAT#: VS-0325-FY124
The anti-IL15 scFv-Fc antibody targets Interleukin-15 (IL15), a cytokine involved in immune regulation and lymphocyte survival. It is designed to neutralize IL15 activity, potentially modulating immune responses in autoimmune and inflammatory diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/785_B10_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/783_B10_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_B_8_5.jpg
Normal Tissue
Figure 6 Lung
Macrophages
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_1_4.jpg
Normal Tissue
Figure 7 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_8_3.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_6_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL15
- Species Reactivity
- Human
- Clone
- 146B7
- Applications
- ELISA, Flow Cytometry, Inhibition
- Related Disease
- Autoimmune and inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 0.1-10 μg/mL
Target
- Alternative Names
- Interleukin 15
- Gene ID
- 3600
- UniProt ID
- P40933
- Long Name
- Interleukin 15
- Sequence Similarities
- Belongs to the IL-15/IL-21 family.
- Cellular Localization
- Cytoplasm; Nucleus; Secreted
- Post Translation Modifications
- Glycosylation at Asn127
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_000576.1; NP_751915.1
- Function
- Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770).
Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.
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Related Diseases
Rheumatoid Arthritis
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 146B7"
- CAT
- Product Name
See other products for "IL15"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-398CL | Human Anti-IL15 Recombinant Antibody (TAB-398CL) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-382CL | Afuco™ Anti-IL15 Recombinant Antibody (AFC-382CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0234CL | Human Anti-IL15 Recombinant Antibody (TAB-0234CL) | ELISA | Human IgG |
| TAB-0235CL | Human Anti-IL15 Recombinant Antibody (TAB-0235CL) | ELISA | Human IgG |
| TAB-0236CL | Human Anti-IL15 Recombinant Antibody (TAB-0236CL) | ELISA | Human IgG |
| TAB-0237CL | Human Anti-IL15 Recombinant Antibody (TAB-0237CL) | ELISA | Human IgG |
| TAB-0238CL | Human Anti-IL15 Recombinant Antibody (TAB-0238CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-075ZJ | Anti-Human IL-15 Recombinant Antibody (DISC0100) | ELISA | Human antibody |
| TAB-076ZJ | Anti-Human IL-15 Recombinant Antibody (DISC0280) | ELISA | Human antibody |
| TAB-075ZJ-S(P) | Anti-Human IL-15 Recombinant Antibody scFv Fragment (DISC0100) | ELISA | Human antibody |
| TAB-076ZJ-S(P) | Anti-Human IL-15 Recombinant Antibody scFv Fragment (DISC0280) | ELISA | Human antibody |
| TAB-075ZJ-F(E) | Anti-Human IL-15 Recombinant Antibody Fab Fragment (DISC0100) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-198LC | Recombinant Anti-Human IL15 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-198LC-1 | Recombinant Anti-Human IL15 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0784CT | Recombinant Mouse anti-Human IL15 Monoclonal antibody (C-F30) | Neut | |
| HPAB-S0072-YC | Human Anti-IL15 Recombinant Antibody (clone 4H10) | ELISA | Human IgG |
| HPAB-S0073-YC | Human Anti-IL15 Recombinant Antibody (clone 1H3) | ELISA | Human IgG |
| HPAB-S0074-YC | Human Anti-IL15 Recombinant Antibody (clone 3C1) | ELISA | Human IgG |
| HPAB-S0075-YC | Human Anti-IL15 Recombinant Antibody (clone 8C5) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1191CQ | Mouse Anti-IL15 Recombinant Antibody (NEUT-1191CQ) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1192CQ | Mouse Anti-IL15 Recombinant Antibody (clone MM0368-13S34) | WB, Neut | Mouse IgG1 |
| NEUT-1193CQ | Rat Anti-IL15 Recombinant Antibody (clone AIO.3) | Neut | Rat IgG2a, κ |
| NEUT-1195CQ | Mouse Anti-IL15 Recombinant Antibody (clone CBL096) | Neut, WB | Mouse IgG1 |
| NEUT-1196CQ | Mouse Anti-IL15 Recombinant Antibody (clone CBL457) | WB, CyTOF, ICFC, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1194CQ | Mouse Anti-IL15 Recombinant Antibody (clone B-E29) | Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1792 | Rabbit Anti-IL15 Recombinant Antibody (clone DS1792AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-WJ-S(P) | Mouse Anti-IL15 Recombinant Antibody (clone IL15-3); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0072-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 4H10); scFv Fragment | ELISA | Human scFv |
| HPAB-S0073-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 1H3); scFv Fragment | ELISA | Human scFv |
| HPAB-S0074-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 3C1); scFv Fragment | ELISA | Human scFv |
| HPAB-S0075-YC-S(P) | Human Anti-IL15 Recombinant Antibody (clone 8C5); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0359-WJ-F(E) | Mouse Anti-IL15 Recombinant Antibody (clone IL15-3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-S0072-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 4H10); Fab Fragment | ELISA | Human Fab |
| HPAB-S0073-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 1H3); Fab Fragment | ELISA | Human Fab |
| HPAB-S0074-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 3C1); Fab Fragment | ELISA | Human Fab |
| HPAB-S0075-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 8C5); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY276 | Mouse Anti-NHP IL15 Recombinant Antibody (clone 34505) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3487 | Anti-IL15 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC166 | Recombinant Anti-IL15 Eliminating Antibody, pH-Sensitive (VS-0625-YC166) | Antigen-Sweeping In Vivo. | Human IgG |
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