Human Anti-IL15 (clone 146B7) scFv-Fc Chimera (CAT#: VS-0325-FY124)
The anti-IL15 scFv-Fc antibody targets Interleukin-15 (IL15), a cytokine involved in immune regulation and lymphocyte survival. It is designed to neutralize IL15 activity, potentially modulating immune responses in autoimmune and inflammatory diseases.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/if_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/if_selected.jpg
Figure 2 IHC staining of human lymph node
(Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/ihc_selected.jpg
(Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/ihc_selected.jpg
Figure 3 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/785_B10_1_red_green.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/785_B10_1_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/783_B10_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/37738/783_B10_1_red_green.jpg
Figure 5 Cerebral cortex
(Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_B_8_5.jpg
(Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_B_8_5.jpg
Figure 6 Lung
(Macrophages
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_1_4.jpg
(Macrophages
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_1_4.jpg
Figure 7 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_8_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_8_3.jpg
Figure 8 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_6_6.jpg
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_6_6.jpg
Figure 9 Lymph node
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_9_8.jpg
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4457/15421_A_9_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164136-IL15
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL15
- Species Reactivity
- Human
- Clone
- 146B7
- Applications
- ELISA, Flow Cytometry, Inhibition
- Related Disease
- Autoimmune and inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 0.1-10 μg/mL
Target
- Alternative Names
- Interleukin 15
- Gene ID
- 3600
- UniProt ID
- P40933
- Long Name
- Interleukin 15
- Sequence Similarities
- Belongs to the IL-15/IL-21 family.
- Cellular Localization
- Cytoplasm; Nucleus; Secreted
- Post Translation Modifications
- Glycosylation at Asn127
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_000576.1; NP_751915.1
- Function
- Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770).
Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
Rheumatoid Arthritis
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 146B7"
See other products for "IL15"
Select a product category from the dropdown menu below to view related products.
Please select product type
Fab Antibody Products
ScFv Antibody Products
Rat Antibody Products
ADCC Enhanced Antibody Products
IgG Antibody Products
Humanized Antibody Products
Human Antibody Products
Fc Glycosylation Antibody Products
High-mannose Glycoform Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1254z-F(E) | Recombinant Anti-Human IL15 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| HPAB-0238-YC-F(E) | Human Anti-IL15 Recombinant Antibody; Fab Fragment (HPAB-0238-YC-F(E)) | ELISA, FC, FuncS | Human Fab |
| HPAB-S0072-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 4H10); Fab Fragment | ELISA | Human Fab |
| HPAB-S0073-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 1H3); Fab Fragment | ELISA | Human Fab |
| HPAB-S0074-YC-F(E) | Human Anti-IL15 Recombinant Antibody (clone 3C1); Fab Fragment | ELISA | Human Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY124. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Inhib, Cyt
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application:
Application: WB, IHC, ELISA, FC
Application: ELISA, IF, Block, FuncS
Application: Neut, IHC, Activ, FuncS, IF, ELISA
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
