Mouse Anti-IL1A Monoclonal Antibody (clone 3A6F11) (CAT#: VS7-0425-WR135)
This product is a mouse IgG2a antibody that binds to human IL1A. The antibody 3A6F11 can be used for WB and ELISA assays.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Group enriched (HBEC3-KT, hTCEpi, hTERT-HME1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115008-IL1A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115008-IL1A
Specifications
- Immunogen
- Recombinant human IL1A fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human IL1A
- Species Reactivity
- Human
- Clone
- 3A6F11
- Molecule Class
- Cytokines
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Inflammatory diseases like rheumatoid arthritis; Fever; Sepsis; It also has a role in certain cancers.
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha
- Gene ID
- 3552
- UniProt ID
- P01583
- Long Name
- Interleukin 1 Alpha
- Cellular Localization
- Cytoplasm, Nucleus, Secreted
- Post Translation Modifications
- Acetylated within its nuclear localization sequence, which impacts subcellular localization.
Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
- Protein Refseq
- NP_000566.3
- Function
- Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1400z | Mouse Anti-IL1A Recombinant Antibody (clone 23C8) | ELISA, IHC, WB | Mouse IgG2a |
| HPAB-1946-FY | Human Anti-IL1A Recombinant Antibody (HPAB-1946-FY) | ELISA | Humanized IgG1, κ |
| VS3-FY749 | Recombinant Mouse Anti-IL1A Antibody (clone 2D6A5) | ELISA, ICC, FC | Mouse IgG1 |
| VS3-FY750 | Recombinant Mouse Anti-IL1A Antibody (clone 6G4A5) | ELISA, FC | Mouse IgG1 |
| VS-0923-FY99 | Recombinant Mouse Anti-IL1A Antibody (VS-0923-FY99) | ELISA, WB, IHC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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