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Anti-IL1A Recombinant Antibody Products

Anti-IL1A Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs offers a range of high-quality anti-IL-1A recombinant antibody solutions to support global clients' IL-1A-related research projects. Our anti-IL-1A recombinant antibodies are meticulously engineered and rigorously quality-controlled, demonstrating exceptional specificity and sensitivity in a variety of tests such as WB, ELISA, and flow cytometry. Furthermore, we offer reference validation data to ensure the seamless advancement of our clients' projects.

IL-1α: A Promising Target for Inflammatory Disorders

Interleukin-1 alpha (IL-1α) is a crucial pro-inflammatory cytokine primarily produced by immune cells like macrophages and neutrophils, as well as cells lining tissues. This cytokine orchestrates a wide range of biological processes, including immune responses, inflammation, and metabolic regulation. While present in most cells, IL-1α is typically inactive. However, during cell death, it is released in an active form, triggering inflammation and contributing to various diseases. Due to its critical role in inflammation, IL-1α represents a promising therapeutic target for inflammatory disorders.

Alternative Names

IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1; interleukin 1 alpha; IL-1 alpha; IL-1α; hematopoietin 1; H-1; LAF; FAF; BAF; LEM; ETAF; HSP; EP; PIF; B-cell-activating factor; hepatocyte-stimulating factor; fibroblast-activating factor; lymphocyte-activating factor; leukocyte endogenous mediator; proteolysis-inducing factor; serum amyloid A inducer; catabolin; epidermal cell-derived thymocyte-activating factor; endogenous pyrogen.

Background

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].

Protein class

Cancer-related genes, Human disease related genes, Plasma proteins, Transporters

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Macrophages, Glandular and luminal cells, Basal respiratory cells, Endometrial ciliated cells, Club cells, Squamous epithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HBEC3-KT, hTCEpi, hTERT-HME1)

Interaction

Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).

Molecular function

Cytokine, Mitogen, Pyrogen

More Types Infomation

Anti-IL1A rAb Products

Creative Biolabs provides a comprehensive selection of high-quality recombinant anti-IL1A antibodies engineered for optimal performance. Our portfolio predominantly features monoclonal antibodies in diverse formats, catering to a broad spectrum of research needs, from fundamental investigations to preclinical and clinical development. Leveraging our robust platform, our anti-IL-1A recombinant antibodies can serve as state-of-the-art tools to empower groundbreaking research in immunology, cancer biology, and related fields, while accelerating the development of innovative therapeutics targeting IL1A.

Table 1. Featured anti-IL1A recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
ZG-0497J Mouse Anti-IL1A Recombinant Antibody (ZG-0497J) Human Mouse IgG WB, ELISA
HPAB-1946-FY Human Anti-IL1A Recombinant Antibody (HPAB-1946-FY) Human Human IgG1, κ ELISA
HPAB-0728-FY Mouse Anti-IL1A Recombinant Antibody (HPAB-0728-FY) Human Mouse IgG ELISA, Neut
NEUT-1261CQ Mouse Anti-IL1A Recombinant Antibody (clone CBL408) Human Mouse IgG1 FC, CyTOF, Neut
NEUT-1260CQ Mouse Anti-IL1A Recombinant Antibody (clone AS5) Human Mouse IgG1 IHC-P, ELISA, Neut, IHC

Creative Quality Control

Creative Biolabs offers a comprehensive portfolio of recombinant anti-IL1A antibodies meticulously developed and rigorously tested to ensure exceptional quality. Our cutting-edge facilities and scientists meticulously engineer each antibody to precisely target IL1A. Through rigorous quality control measures, we guarantee that these antibodies exhibit superior specificity, high binding affinity, and excellent performance across a wide range of research applications.

Fig.1 WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-IL-1A antibody
(Cat# ZG-0497J, Creative Biolabs).

Customer Reviews

Excellent
Je***a
Mouse Anti-IL1A Recombinant Antibody (clone CBL781) (NEUT-1262CQ)
I recently purchased Creative Biolabs' anti-IL-1A recombinant antibody for WB experiments. I determined the concentration according to the instructions provided with the product. The experimental results showed that at this concentration, the antibody was sensitive and specific, with no non-specific binding. At the same time, I also tested other concentrations, and the comparison results showed that the effect at the recommended concentration was better than other concentrations.
20/Mar/2023
Excellent
Tr***p
Recombinant Mouse Anti-IL1A Antibody (VS-0923-FY99) (VS-0923-FY99)
We were impressed by the quality and performance of the anti-IL1A recombinant antibodies from Creative Biolabs. The antibodies exhibited excellent specificity and sensitivity in our WB and IHC experiments. The consistent lot-to-lot reproducibility further enhanced our confidence in their reliability for our research.
11/Jun/2023
Excellent
Yo***g
Mouse Anti-IL1A Recombinant Antibody (clone 3D12.E3) (VS-0724-XY83)
Creative Biolabs offered excellent customer service throughout our project. Their skilled scientific team was quickly accessible to answer our concerns and offer technical assistance. The high quality of the anti-IL1A antibodies, combined with their excellent customer support, made our research experience seamless and productive.
20/Nov/2024

rAb Production

Creative Biolabs provides a steady supply of high-quality anti-IL1A antibodies produced utilizing cutting-edge genetic engineering techniques, ensuring consistent performance and availability for your research requirements.

Featured Anti-IL1A Recombinant Antibody Production PlatformsFig.2 Milligram-scale. (Creative Biolabs Original)
Fig.2 Milligram-scale anti-IL1A recombinant antibody production.

Fig.3 Gram-scale. (Creative Biolabs Original)Fig.3 Gram-scale anti-IL1A recombinant antibody production.

rAb Modalities

Creative Biolabs offers a comprehensive selection of high-quality anti-IL1A recombinant antibodies in a variety of forms to combat the unique needs of global researchers.

Fig.4 IL1A antibody production and modalities. (Creative Biolabs Original)Fig.4 Full-length anti-IL1A recombinant antibody production and modalities.

IL1A-Targeted Drug Information

Table 2. Public drug targeting IL1A.

Company Research Phase Classification Condition
Abbott
AbbVie (Originator)
Phase III Bispecific Antibodies
Humanized Monoclonal Antibodies
Hidradenitis suppurativa
Osteoarthritis, hand
Osteoarthritis, knee
Ulcerative colitis
XBiotech (Originator) Phase II Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer, colorectal
Cancer, pancreas
Osteoarthritis
Rheumatoid arthritis
Janssen
Janssen Biotech (Janssen)
MegaPharm
XBiotech (Originator)
Phase II Cancer Immunotherapy
Human Monoclonal Antibodies
Acne vulgaris
Atherosclerosis
Atopic dermatitis
Cachexia, cancer related
Cancer
Cancer, colorectal
Cancer, colorectal, metastatic
Cancer, lung (non-small cell) (NSCLC)
Cancer, ovary
Cancer, pancreas
Diabetes type 2
Hidradenitis suppurativa
Leukemia
Plaque psoriasis
Pyoderma gangrenosum
Restenosis, arterial
Rheumatoid arthritis
Scleroderma, systemic (Sclerosis, systemic)
vascular disease, peripheral
XBiotech (Originator) Phase I Human Monoclonal Antibodies Stroke, ischemic
Universitaet Zuerich (Originator)
XBiotech (Originator)
Preclinical Murine Monoclonal Antibodies Ischemia-reperfusion injury, cerebral
Stroke, ischemic
AbbVie (Originator) Preclinical Bispecific Antibodies
Diabodies
Rheumatoid arthritis
Chengdu Easton Pharmaceutical (Originator) Biological Testing Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Fibrosis
Immunological Disorders
Inflammatory disorders
Respiratory Disorders
Chengdu Easton Pharmaceutical (Originator) Biological Testing Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Fibrosis
Immunological Disorders
Inflammatory disorders
Respiratory Disorders
XBiotech (Originator) Biological Testing Cancer Immunotherapy
Human Monoclonal Antibodies
Cancer
Inflammatory disorders
XBiotech (Originator) Biological Testing Human Monoclonal Antibodies Inflammatory disorders

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As a leading company in the antibody research industry, Creative Biolabs continues to improve and innovate based on years of project experience, promoting the application of our antibodies in global biological research. If you want to learn more or make an order, please feel free to reach out to us.

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