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For Research Use Only. Not For Clinical Use.
Creative Biolabs offers a range of high-quality anti-IL-1A recombinant antibody solutions to support global clients' IL-1A-related research projects. Our anti-IL-1A recombinant antibodies are meticulously engineered and rigorously quality-controlled, demonstrating exceptional specificity and sensitivity in a variety of tests such as WB, ELISA, and flow cytometry. Furthermore, we offer reference validation data to ensure the seamless advancement of our clients' projects.
Interleukin-1 alpha (IL-1α) is a crucial pro-inflammatory cytokine primarily produced by immune cells like macrophages and neutrophils, as well as cells lining tissues. This cytokine orchestrates a wide range of biological processes, including immune responses, inflammation, and metabolic regulation. While present in most cells, IL-1α is typically inactive. However, during cell death, it is released in an active form, triggering inflammation and contributing to various diseases. Due to its critical role in inflammation, IL-1α represents a promising therapeutic target for inflammatory disorders.
IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1; interleukin 1 alpha; IL-1 alpha; IL-1α; hematopoietin 1; H-1; LAF; FAF; BAF; LEM; ETAF; HSP; EP; PIF; B-cell-activating factor; hepatocyte-stimulating factor; fibroblast-activating factor; lymphocyte-activating factor; leukocyte endogenous mediator; proteolysis-inducing factor; serum amyloid A inducer; catabolin; epidermal cell-derived thymocyte-activating factor; endogenous pyrogen.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].
Cancer-related genes, Human disease related genes, Plasma proteins, Transporters
Intracellular, Secreted (different isoforms)
Cell type enhanced (Macrophages, Glandular and luminal cells, Basal respiratory cells, Endometrial ciliated cells, Club cells, Squamous epithelial cells)
Not detected in immune cells
Group enriched (HBEC3-KT, hTCEpi, hTERT-HME1)
Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).
Cytokine, Mitogen, Pyrogen
Creative Biolabs provides a comprehensive selection of high-quality recombinant anti-IL1A antibodies engineered for optimal performance. Our portfolio predominantly features monoclonal antibodies in diverse formats, catering to a broad spectrum of research needs, from fundamental investigations to preclinical and clinical development. Leveraging our robust platform, our anti-IL-1A recombinant antibodies can serve as state-of-the-art tools to empower groundbreaking research in immunology, cancer biology, and related fields, while accelerating the development of innovative therapeutics targeting IL1A.
Table 1. Featured anti-IL1A recombinant antibody products at Creative Biolabs.
Cat. No. | Product Name | Target Species | Host Species | Applications |
ZG-0497J | Mouse Anti-IL1A Recombinant Antibody (ZG-0497J) | Human | Mouse IgG | WB, ELISA |
HPAB-1946-FY | Human Anti-IL1A Recombinant Antibody (HPAB-1946-FY) | Human | Human IgG1, κ | ELISA |
HPAB-0728-FY | Mouse Anti-IL1A Recombinant Antibody (HPAB-0728-FY) | Human | Mouse IgG | ELISA, Neut |
NEUT-1261CQ | Mouse Anti-IL1A Recombinant Antibody (clone CBL408) | Human | Mouse IgG1 | FC, CyTOF, Neut |
NEUT-1260CQ | Mouse Anti-IL1A Recombinant Antibody (clone AS5) | Human | Mouse IgG1 | IHC-P, ELISA, Neut, IHC |
Creative Biolabs offers a comprehensive portfolio of recombinant anti-IL1A antibodies meticulously developed and rigorously tested to ensure exceptional quality. Our cutting-edge facilities and scientists meticulously engineer each antibody to precisely target IL1A. Through rigorous quality control measures, we guarantee that these antibodies exhibit superior specificity, high binding affinity, and excellent performance across a wide range of research applications.
Fig.1 WB analysis of anti-IL-1A antibody
(Cat# ZG-0497J, Creative Biolabs).
Creative Biolabs provides a steady supply of high-quality anti-IL1A antibodies produced utilizing cutting-edge genetic engineering techniques, ensuring consistent performance and availability for your research requirements.
Featured Anti-IL1A Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-IL1A recombinant antibody production.
Fig.3 Gram-scale anti-IL1A recombinant antibody production.
Creative Biolabs offers a comprehensive selection of high-quality anti-IL1A recombinant antibodies in a variety of forms to combat the unique needs of global researchers.
Fig.4 Full-length anti-IL1A recombinant antibody production and modalities.
Table 2. Public drug targeting IL1A.
Company | Research Phase | Classification | Condition |
Abbott AbbVie (Originator) |
Phase III |
Bispecific Antibodies Humanized Monoclonal Antibodies |
Hidradenitis suppurativa Osteoarthritis, hand Osteoarthritis, knee Ulcerative colitis |
XBiotech (Originator) | Phase II |
Cancer Immunotherapy Human Monoclonal Antibodies |
Cancer, colorectal Cancer, pancreas Osteoarthritis Rheumatoid arthritis |
Janssen Janssen Biotech (Janssen) MegaPharm XBiotech (Originator) |
Phase II |
Cancer Immunotherapy Human Monoclonal Antibodies |
Acne vulgaris Atherosclerosis Atopic dermatitis Cachexia, cancer related Cancer Cancer, colorectal Cancer, colorectal, metastatic Cancer, lung (non-small cell) (NSCLC) Cancer, ovary Cancer, pancreas Diabetes type 2 Hidradenitis suppurativa Leukemia Plaque psoriasis Pyoderma gangrenosum Restenosis, arterial Rheumatoid arthritis Scleroderma, systemic (Sclerosis, systemic) vascular disease, peripheral |
XBiotech (Originator) | Phase I | Human Monoclonal Antibodies | Stroke, ischemic |
Universitaet Zuerich (Originator) XBiotech (Originator) |
Preclinical | Murine Monoclonal Antibodies |
Ischemia-reperfusion injury, cerebral Stroke, ischemic |
AbbVie (Originator) | Preclinical |
Bispecific Antibodies Diabodies |
Rheumatoid arthritis |
Chengdu Easton Pharmaceutical (Originator) | Biological Testing |
Cancer Immunotherapy Humanized Monoclonal Antibodies |
Cancer Fibrosis Immunological Disorders Inflammatory disorders Respiratory Disorders |
Chengdu Easton Pharmaceutical (Originator) | Biological Testing |
Cancer Immunotherapy Humanized Monoclonal Antibodies |
Cancer Fibrosis Immunological Disorders Inflammatory disorders Respiratory Disorders |
XBiotech (Originator) | Biological Testing |
Cancer Immunotherapy Human Monoclonal Antibodies |
Cancer Inflammatory disorders |
XBiotech (Originator) | Biological Testing | Human Monoclonal Antibodies | Inflammatory disorders |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
As a leading company in the antibody research industry, Creative Biolabs continues to improve and innovate based on years of project experience, promoting the application of our antibodies in global biological research. If you want to learn more or make an order, please feel free to reach out to us.