Anti-ITGB1 (clone W24V185) Recombinant Antibody Coupled Liposome (VS-1024-FY186)
CAT#: VS-1024-FY186
ID1 is a transcription factor that plays a critical role in the initiation and progression of melanoma, a particularly aggressive form of skin cancer. By conjugating anti-ID1 antibodies to liposomes, researchers have developed a novel strategy that enables the precise targeting of malignant cells, thereby enhancing the delivery of therapeutic agents directly to the tumor site. This targeted approach has the potential to not only inhibit tumor growth but also to reduce the risk of metastasis, offering a more effective treatment option for patients battling this challenging disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3434/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line BJ
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69003/165766_B_5_7_selected.jpg
Normal Tissue
Figure 3 Immunofluorescent staining of human cell line BJ
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3434/ihc_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59297/139504_A_7_5.jpg
Normal Tissue
Figure 5 Smooth muscle
Smooth muscle cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59297/139504_B_6_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150093-ITGB1
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V185
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that has been specifically developed to target and bind to the integrin beta 1 subunit (ITGB1). The design and production of this antibody involved advanced biotechnological techniques that enable it to recognize ITGB1 with high specificity and affinity.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ITGB1
- Introduction
- Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
- Alternative Names
- Integrin Subunit Beta 1
- Full Name
- Integrin Subunit Beta 1
- Gene ID
- 3688
- UniProt ID
- P05556
- Sequence Similarities
- Belongs to the integrin beta chain family.
- Cellular Localization
- Cell junction, Cell membrane, Cell projection, Endosome, Membrane
- Post Translation Modifications
- The cysteine residues are involved in intrachain disulfide bonds.
- Protein Refseq
- NP_002202.2; NP_391988.1; NP_596867.1
- Function
- Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099).
ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity).
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Datasheet
MSDS
COA
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|---|---|---|---|
| TAB-772LC | Anti-human ITGB1 Recombinant Antibody (1B4) (TAB-772LC) | FuncS | |
| TAB-772LC-S(P) | Anti-human ITGB1 scFv Fragment (1B4) | ELISA | |
| TAB-772LC-F(E) | Anti-human ITGB1 Fab Fragment (1B4) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0277MZ | Chicken Anti-Integrin β1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1585CQ | Recombinant Mouse Anti-ITGB1 Antibody (CBL252) | FC, ELISA, WB, IP, FuncS, Inhib | IgG1 |
| NEUT-1587CQ | Recombinant Mouse Anti-ITGB1 Antibody (P5D2) | BL, FC, IP, CyTOF, ICC | IgG1 |
| NEUT-1588CQ | Recombinant Armenian Hamster Anti-Itgb1 Antibody (HMβ1-1) | FC, IP, BL, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1586CQ | Recombinant Mouse Anti-ITGB1 Antibody (P4C10) | WB, Neut, ELISA, FC, ICC, IF, IHC-Fr, IP | IgG1 |
| NEUT-1589CQ | Recombinant Armenian hamster Anti-Itgb1 Antibody (HMb1-1) | FC, FuncS, Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1882 | Hi-Affi™ Recombinant Rabbit Anti-ITGB1 Monoclonal Antibody (DS1882AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-047CN | Human Anti-ITGB1 Recombinant Antibody | ELISA, WB, IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-047CN-F(E) | Human Anti-ITGB1 Recombinant Antibody; Fab Fragment | ELISA, WB, IHC | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-047CN-S(P) | Human Anti-ITGB1 Recombinant Antibody; scFv Fragment | ELISA, WB, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS3-XY928 | Mouse Anti-ITGB1 Recombinant Antibody (clone 4ATS2/16.2.1) | FC, IF | Mouse IgG1 |
| VS3-XY933 | Mouse Anti-ITGB1 Recombinant Antibody (clone 3B6G3) | IHC, FC | Mouse IgG1 |
| MOB-399YC | Mouse Anti-ITGB1 Recombinant Antibody (MOB-399YC), PE Conjugated | FC | Mouse IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY161 | AbPlus™ Anti-ITGB1 Magnetic Beads (P4C10) | IP, Protein Purification | |
| VS-0724-YC1500 | AbPlus™ Anti-Itgb1 Magnetic Beads (VS-0724-YC1500) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC53 | Rabbit Anti-ITGB1 Antibody (VS-0924-YC53) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY289 | Mouse Anti-NHP ITGB1 Recombinant Antibody (clone 3B6) | WB, IHC, FC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY152 | CytoStream™ Mouse Anti-ITGB1 Recombinant Antibody (VS-0225-XY152) | FC | Mouse IgG1, kappa |
| VS13-YC603 | CytoStream™ Rabbit Anti-ITGB1 Recombinant Antibody (VS13-YC603) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1156 | Anti-ITGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3653 | Anti-Mouse ITGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3655 | Anti-Human ITGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3654 | Anti-Porcine ITGB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC597 | Recombinant Anti-ITGB1 Vesicular Antibody, EV Displayed (VS-0425-YC597) | Block, ELISA, FC, Cell-uptake |
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