Mouse Anti-KLRK1 Recombinant Antibody (VS3-FY2752) (CAT#: VS3-FY2752)
The anti-KLRK1 product is a recombinant mouse monoclonal antibody that binds to CD314 protein, a calculated weight of 25.3 kDa. It cross-reacts with human, rat. This monoclonal antibody is potential for conducting research on Immune diseases and cancer. This monoclonal antibody can be used in Western Blot, Flow cytometry, ELISA.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68877/1695_B6_3_cr57d8507991e89_selected.jpg
Figure 2 High expression in spleen.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_8_5_val_selected.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_A_7_8.jpg
Figure 5 Spleen
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21896/49188_B_7_4.jpg
Figure 6 RNA cell line category: Cell line enriched (U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000213809-KLRK1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Killer cell lectin like receptor K1 of human and rat origins
- Species Reactivity
- Human, Rat
- Applications
- WB, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 25.3 kDa.
- Related Disease
- Immune diseases and cancer
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- Killer Cell Lectin Like Receptor K1; Killer Cell Lectin-Like Receptor Subfamily K, Member 1; NKG2-D-Activating NK Receptor; NK Cell Receptor D; D12S2489E; NKG2D; DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence
- Gene ID
- 22914
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn131, Asn163, and Asn202
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- NP_031386.2
- Function
- Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.
Stimulates perforin-mediated elimination of ligand-expressing tumor cells.
Signaling involves calcium influx, culminating in the expression of TNF-alpha.
Participates in NK cell-mediated bone marrow graft rejection.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KLRK1"
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0002CL | Human Anti-KLRK1 Recombinant Antibody (TAB-0002CL) | ELISA, WB, FC, RIA, Block, IA | Human IgG4 |
| TAB-0002CL-S(P) | Human Anti-KLRK1 Recombinant Antibody; scFv Fragment (TAB-0002CL-S(P)) | ELISA, WB, FC, RIA, Block, IA | Human scFv |
| TAB-520MZ | Anti-Human KLRK1 Recombinant Antibody (KYK-1.0) | ELISA | Human antibody |
| TAB-521MZ | Anti-Human KLRK1 Recombinant Antibody (KYK-2.0) | Cyt, ELISA, FC, FuncS | Human antibody |
| TAB-520MZ-F(E) | Anti-Human KLRK1 Recombinant Antibody Fab Fragment (KYK-1.0) | SDS-PAGE, ELISA | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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