Rabbit Anti-LAMP1 Recombinant Antibody (VS13-YC644) (CAT#: VS13-YC644)

• Immunogen
• Recombinant mouse LAMP1, aa 371-406.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat LAMP1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC-P, IHC-Fr, ICC, IF, IP

• Conjugate
• NONE

• Related Disease
• Salla Disease and Hermansky-Pudlak Syndrome

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.4) containing 40% Glycerol and 0.1% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/1000-1/2000
  Immunohistochemistry-paraffin (IHC-P): 1/10000
  Immunofluorescence (IF-tissue): 1/500-1/2000
  Immunohistochemistry-frozen (IHC-Fr): 1/1000
  Immunoprecipitation (IP): 1-2 μg per 500 μL of cell lysate

• Alternative Names
• Lysosomal Associated Membrane Protein 1 Lysosome-Associated Membrane Protein 1; CD107 Antigen-Like Family Member A; LAMP-1

• Gene ID
• 3916

• UniProt ID
• P11279

• Long Name
• Lysosomal Associated Membrane Protein 1

• Sequence Similarities
• Belongs to the LAMP family.

• Cellular Localization
• Cell membrane; Endosome; Lysosome; Membrane

• Protein Refseq
• NP_005552.3

• Function
• Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
  Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
  Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
  In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
  Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisBy Similarity3 Publications
  (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
  Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).2 Publications
  (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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