Rabbit Anti-LAMP1 Recombinant Antibody (VS13-YC644)
CAT#: VS13-YC644
The Rabbit Anti-LAMP1 Recombinant Antibody is specific for human, mouse and rat LAMP1. LAMP1, coding lysosomal-associated membrane glycoproteins, presents selectin ligands and may link to tumor metastasis. It's involved in pathways related to hematopoietic stem cell differentiation. The anti-LAMP1 antibody can be used for Western blot (1/1000-1/2000), Immunohistochemistry-paraffin (1/10000), Immunofluorescence of tissues (1/500-1/2000), Immunohistochemistry-frozen (1/1000), Immunoprecipitation (1-2 μg per 500 μL of cell lysate).
Gene Expression
Normal Tissue
Figure 1 Ihc staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong granular positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14750/34136_A_5_5_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity(granular pattern) in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_B_9_5.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_4.jpg
Normal Tissue
Figure 5 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_1_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4260/19501_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185896-LAMP1
❮
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Specifications
- Immunogen
- Recombinant mouse LAMP1, aa 371-406.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LAMP1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, IHC-Fr, ICC, IF, IP
- Conjugate
- NONE
- Related Disease
- Salla Disease and Hermansky-Pudlak Syndrome
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 40% Glycerol and 0.1% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/10000
Immunofluorescence (IF-tissue): 1/500-1/2000
Immunohistochemistry-frozen (IHC-Fr): 1/1000
Immunoprecipitation (IP): 1-2 μg per 500 μL of cell lysate
Target
- Alternative Names
- Lysosomal Associated Membrane Protein 1 Lysosome-Associated Membrane Protein 1; CD107 Antigen-Like Family Member A; LAMP-1
- Gene ID
- 3916
- UniProt ID
- P11279
- Long Name
- Lysosomal Associated Membrane Protein 1
- Sequence Similarities
- Belongs to the LAMP family.
- Cellular Localization
- Cell membrane; Endosome; Lysosome; Membrane
- Protein Refseq
- NP_005552.3
- Function
- Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Also plays an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasisBy Similarity3 Publications
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).2 Publications
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-611-S(P) | Recombinant Anti-human LAMP1 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-611-S(P) | Recombinant Human Anti-human LAMP1 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-0035-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0035-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0036-LSX-S(P) | Human Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0036-LSX-S(P)) | ELISA, IHC | Human scFv |
| HPAB-0037-LSX-S(P) | Mouse Anti-LAMP1 Recombinant Antibody; scFv Fragment (HPAB-0037-LSX-S(P)) | ELISA, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2010 | Hi-Affi™ Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (DS2010AB) | WB, IHC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0035-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0035-LSX) | ELISA, IHC, ADCC | Human IgG |
| HPAB-0036-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0036-LSX) | ELISA, IHC, ADCC, FuncS | Human IgG |
| HPAB-0037-LSX | Human Anti-LAMP1 Recombinant Antibody (HPAB-0037-LSX) | ELISA, IHC | Chimeric (mouse/human) IgG |
| MRO-0916-CN | Recombinant Rabbit Anti-LAMP1 Monoclonal Antibody (JJ0940) | WB, IHC | Rabbit IgG |
| VS3-WK520 | Rabbit Anti-LAMP1 Recombinant Antibody (clone JJ0940) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0035-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0035-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0036-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0036-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0037-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0037-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0038-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0038-LSX-F(E)) | ELISA, IHC | Human Fab |
| HPAB-0039-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0039-LSX-F(E)) | ELISA, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC849 | AbPlus™ Anti-LAMP1 Magnetic Beads (VS-0724-YC849) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY301 | Mouse Anti-NHP LAMP1 Recombinant Antibody (clone H4A3) | WB, IHC, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC666 | Recombinant Anti-LAMP1 Vesicular Antibody, EV Displayed (VS-0425-YC666) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3937 | Anti-LAMP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3938 | Anti-Mouse LAMP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3939 | Anti-Human LAMP1 Immunohistochemistry Kit | IHC |
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