Anti-LRP6 Antibody Prodrug, Protease Activated (VS-1025-YC214)

Name: Anti-LRP6 Antibody Prodrug, Protease Activated (VS-1025-YC214)
SKU: VS-1025-YC214
Rating: 5 (1 reviews)

CAT#: VS-1025-YC214

The Anti-LRP6 Antibody Prodrug, Protease Activated (VS-1025-YC214) is an antibody prodrug comprised of a recombinant mouse antibody targeting human LRP6, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to LRP6 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to LRP6 effectively. LRP6 (LDL Receptor Related Protein 6) is a co-receptor that plays an essential role in activating the Wnt signaling pathway. Its overexpression or gene amplification is associated with the activation of oncogenic Wnt signaling in various cancers, including breast and liver, promoting proliferation.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IHC staining of human colon

Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg

Normal Tissue Figure 2 IHC staining of human kidney

High expression. RNA expression: 4.4 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg

Normal Tissue Figure 3 IHC staining of human lymph node

Low expression. RNA expression: 0.8 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg

Normal Tissue Figure 5 Liver

Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg

Normal Tissue Figure 6 Testis

Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6

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Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human LRP6

Target
LRP6

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Alternative Names
LRP6; low density lipoprotein receptor-related protein 6; ADCAD2

Gene ID
4040

UniProt ID
O75581

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Related Signaling Pathways

Canonical Wnt Signaling Pathway

JAK-STAT Signaling Pathway

Non-Canonical Wnt Signaling Pathway

Related Diseases

Hepatocellular Carcinoma

Pancreatic Cancer

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-1025-YC214.pdf

MSDS

MSDS - VS-1025-YC214.pdf

COA

Certificate of Analysis Lookup

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