Recombinant Anti-MBP (AA 65-92 x AA 130-156) Biparatopic Antibody, Tandem scFv (Clone E6 x Clone D1)
CAT#: VS-0525-YC123
The Recombinant Anti-MBP (AA 65-92 x AA 130-156) Biparatopic Antibody, Tandem scFv (Clone E6 x Clone D1) is a biparatopic antibody (bpAb) that binds two distinct Myelin Basic Protein (MBP) epitopes. Its tandem scFv design positions the E6 scFv (targeting amino acids 65-92 of MBP) N-terminally to the D1 scFv (specific for amino acids 130-156 of MBP).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
nuclear
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_9_5.jpg
Normal Tissue
Figure 3 Caudate
Glial cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_8_7.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HL-60, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- EBV MBP
- Species Reactivity
- EBV
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- E6
- Clone 2
- D1
- Epitope 1
- aa 65-92
- Epitope 2
- aa 130-156
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, IP, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Myelin Basic Protein
Target
- Introduction
- The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.
- Alternative Names
- MBP
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Related Diseases
Asthma
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MHC-LC1274 | PE-DRB2/Human MBP (ENPVVHFFKNIVTPRGGSGGGGG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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