MBP antibody (E2) was selected toward myelin basic protein (MBP), one of the major myelin antigens. Clone E2 has been shown to react with both MBP and LMP1 proteins in vitro, suggesting natural cross-reactivity.
Figure 1 Characterization of antigen specificity of selected soluble scFv.
Relative anti-MBP activity of the D1, B5V6, E2, E6, and F11 scFv, analyzed by ELISA.
Gabibov, A. G., Belogurov, A. A., Jr, Lomakin, Y. A., Zakharova, M. Y., Avakyan, M. E., Dubrovskaya, V. V., Smirnov, I. V., Ivanov, A. S., Molnar, A. A., Gurtsevitch, V. E., Diduk, S. V., Smirnova, K. V., Avalle, B., Sharanova, S. N., Tramontano, A., Friboulet, A., Boyko, A. N., Ponomarenko, N. A., & Tikunova, N. V. (2011). Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 25(12), 4211–4221.
Figure 2 Quantitative characteristics of the scFv affinity to MBP were measured by the SPR approach.
Respective Kd values are specified. ND, not detectable.
Gabibov, A. G., Belogurov, A. A., Jr, Lomakin, Y. A., Zakharova, M. Y., Avakyan, M. E., Dubrovskaya, V. V., Smirnov, I. V., Ivanov, A. S., Molnar, A. A., Gurtsevitch, V. E., Diduk, S. V., Smirnova, K. V., Avalle, B., Sharanova, S. N., Tramontano, A., Friboulet, A., Boyko, A. N., Ponomarenko, N. A., & Tikunova, N. V. (2011). Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 25(12), 4211–4221.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1126z | Mouse Anti-MBP Recombinant Antibody (clone 34D11) | WB, FuncS | Mouse IgG |
FAMAB-0216CQ | Mouse Anti-MBP Recombinant Antibody (clone 845D3) | ELISA, WB, IB | Mouse IgG1, κ |
FAMAB-0221-CN | Recombinant Human Anti-MBP Antibody (B5V6) | WB, ELISA, IP | Human IgG1 |
VS3-CJ303 | Mouse Anti-MBP Recombinant Antibody (clone ABT-MBP) | IHC-P | Mouse IgG1, κ |
VS3-CJ304 | Mouse Anti-MBP Recombinant Antibody (VS3-CJ304) | IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-174LC | Recombinant Anti-MBP Antibody (Non-glycosylated) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0807MZ | Chicken Anti-MBP Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2184 | Hi-Affi™ Recombinant Rabbit Anti-MBP Monoclonal Antibody (DS2184AB) | IHC-FoFr, IHC-P | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0216CQ-F(E) | Mouse Anti-MBP Recombinant Antibody (clone 845D3); Fab Fragment | ELISA, WB | Mouse Fab |
FAMAB-0107-CN-F(E) | Mouse Anti-MBP Recombinant Antibody (clone IN-1); Fab Fragment | WB, IF, IP, Block | Mouse Fab |
FAMAB-0217-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E2) | WB, ELISA, IP | Human Fab |
FAMAB-0218-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (F11) | WB, ELISA, IP | Human Fab |
FAMAB-0219-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E6) | WB, ELISA, IP | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0216CQ-S(P) | Mouse Anti-MBP Recombinant Antibody (clone 845D3); scFv Fragment | ELISA, WB | Mouse scFv |
FAMAB-0217-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (E2) | WB, ELISA, IP | Human scFv |
FAMAB-0218-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (F11) | WB, ELISA, IP | Human scFv |
FAMAB-0219-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (E6) | WB, ELISA, IP | Human scFv |
FAMAB-0220-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (D1) | WB, ELISA, IP | Human scFv |
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