Human Anti-MBP (clone W25MBP10) scFv-Fc Chimera (CAT#: VS-0125-FY31)
This product is a fusion protein consisting of a single-chain antibody Fc (scFv-Fc), named W25MBP10. It is composed of an Fv domain that targets Maltose Binding Protein (MBP) connected to a single-chain Fc. The expression of W25MBP10 is used to study intracellular glycosylation processes, particularly when comparing wild-type plants and the alg3-2 mutant plants, allowing researchers to analyze the differences in N-glycosylation heterogeneity and functionality between the two.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
nuclear
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_9_5.jpg
(Endothelial cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
nuclear
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_9_5.jpg
Figure 3 Caudate
(Glial cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_8_7.jpg
(Glial cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_8_7.jpg
Figure 4 RNA cell line category: Cell line enhanced (HL-60, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
Figure 4 RNA cell line category: Cell line enhanced (HL-60, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- W25MBP10
- Applications
- Antibody-dependent cellular cytotoxicity, Complement-dependent cytolysis
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- anti-MBP scFv-Fc is a fusion protein that combines the specificity of a monoclonal antibody with the functionality of an Fc fragment, enabling it to specifically recognize and bind to MBP. This fusion protein has enhanced stability and a longer half-life, making it well-suited for therapeutic applications in biomedicine. Additionally, the Fc fragment can mediate antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytolysis (CDC), providing potential applications in immunotherapy. anti-MBP scFv-Fc shows promising prospects in biological research, vaccine development, diagnostic reagents, and treatment methods for MBP-related diseases, making it a versatile biological tool.
Target
- Alternative Names
- Myelin Basic Protein; Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Golli-MBP
- Gene ID
- 4155
- UniProt ID
- P02686
- Cellular Localization
- Cell membrane, Membrane, Nucleus
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
Asthma
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1126z | Mouse Anti-MBP Recombinant Antibody (clone 34D11) | WB, FuncS | Mouse IgG |
| FAMAB-0217-CN | Recombinant Human Anti-MBP Antibody (E2) | WB, ELISA, IP | Human IgG1 |
| FAMAB-0218-CN | Recombinant Human Anti-MBP Antibody (F11) | WB, ELISA, IP | Human IgG1 |
| MOB-0127F | Mouse Anti-MBP Recombinant Antibody (MOB-0127F) | IHC-P, IF | Mouse IgG |
| MOB-0128F | Mouse Anti-MBP Recombinant Antibody (MOB-0128F) | IHC-P, IF | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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