MBP (myelin basic protein) is a protein involved in the myelination of nerves in the CNS. Myelin basic protein functions to maintain the correct structure of myelin, through its interaction with the lipids in the myelin membrane. The myelin sheath is made up of MBP and lipids, and functions as an insulator to increase the velocity of axonal impulse conduction. Myelin basic protein plays a role in the demyelinating disease multiple sclerosis (MS). A hallmark of the disease is the loss of the myelin sheath surrounding nerves, thought to be induced by antibodies against MBP.

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