Rabbit Anti-PCNA Recombinant Antibody (clone R04-3I2) (CAT#: VS3-FY1817)
This R04-3I2 recombinant monoclonal antibody has the ability to specifically bind to human PCNA. It cross-reacts with mouse. This PCNA antibody has been teted positive by western blot analysis of PCNA in Hela lysates.
Specific Inquiry
WB
Figure 1 Anti-PCNA Antibody (VS3-FY1817) in WB.
The PCNA expression in Hela lysates were detected using the anti-PCNA by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human PCNA
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse PCNA
- Species Reactivity
- Human, Mouse
- Clone
- R04-3I2
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 29 kDa, while the observed molecular weight stands at 29 kDa.
- Related Disease
- Ataxia-Telangiectasia-Like Disorder 2 and Bowen's Disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/5000-1/10000
Target
- Alternative Names
- Proliferating Cell Nuclear Antigen; Cyclin; DNA Polymerase Delta Auxiliary Protein; ATLD2
- Gene ID
- 5111
- UniProt ID
- P12004
- Sequence Similarities
- Belongs to the PCNA family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated; Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation; Ubiquitinated
- Protein Refseq
- NP_002583.1; NP_872590.1
- Function
- Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2616 | Hi-Affi™ Recombinant Rabbit Anti-PCNA Monoclonal Antibody (DS2616AB) | FC, IHC-P, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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