Afuco™ Anti-PDGFRA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-878)
CAT#: AFC-TAB-878
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human CD140a. It is a monoclonal antibody designed for the treatment of cancer
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4947/1030_B8_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Fibroblasts Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_7_5.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HHSteC, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134853-PDGFRA
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut
- Conjugate
- Unconjugated
- Generic Name
- Tovetumab
- Related Disease
- Glioblastoma multiforme (GBM)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Tovetumab"
Anti-Human CD140a Recombinant Antibody (Tovetumab)Recombinant human monoclonal antibody expressed in CHO binding to human CD140a. Tovetumab is a monoclonal antibody designed for the treatment of cancer
DrugMonitor™ Anti-Tovetumab Antibody (VS-1224-YC1230)Tovetumab is an anti-PDGFRa monoclonal antibody designed for treating cancer, studied in trials for glioblastoma multiforme and advanced solid malignancies. The DrugMonitor™ Anti-Tovetumab Antibody (VS-1224-YC1230) is an anti-drug antibody (ADA) against Tovetumab. This drug-based antibody is raised in mice immunized with the Tovetumab. The anti-Tovetumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Tovetumab in samples.
See other products for "PDGFRA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192 | Anti-Human PDGF-R alpha Recombinant Antibody (Olaratumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| TAB-878 | Anti-Human CD140a Recombinant Antibody (Tovetumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 - kappa |
| TAB-1063CL | Human Anti-PDGFRA Recombinant Antibody (TAB-1063CL) | FuncS | Human antibody |
| TAB-1063CL-S(P) | Human Anti-PDGFRA Recombinant Antibody; scFv Fragment (TAB-1063CL-S(P)) | ELISA | Human scFv |
| TAB-1063CL-F(E) | Human Anti-PDGFRA Recombinant Antibody; Fab Fragment (TAB-1063CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1848CQ | Recombinant Rat Anti-Pdgfra Antibody (APA5) | FC, FuncS, IHC-Fr, Neut, WB | IgG2a, κ |
| NEUT-1849CQ | Recombinant Mouse Anti-PDGFRA Antibody (CBL458) | WB, IHC, Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2637 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRA Monoclonal Antibody (DS2637AB) | WB | IgG |
| MOR-4662 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRA Monoclonal Antibody (TH176DS) | WB, IF, ICC, ChIP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0233LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1) | Inhib, FC | Human IgG1 |
| HPAB-0234LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3) | Inhib, FC | Human IgG1 |
| HPAB-0235LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2) | Inhib, FC | Human IgG1 |
| HPAB-0236LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3) | Inhib, FC | Human IgG1 |
| HPAB-0237LY | Human Anti-PDGFRA Recombinant Antibody (clone 2.1576.1. 2) | Inhib, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.175.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0233LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0234LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0235LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0236LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3); scfv Fragment | Inhib, FC | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.175.3); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0233LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0234LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0235LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0236LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3); Fab Fragment | Inhib, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-192 | Afuco™ Anti-PDGFRA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-192) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY164 | Human Anti-PDGFRA (clone 2.175.3) scFv-Fc Chimera | Inhib, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC216 | Recombinant Anti-PDGFRA Vesicular Antibody, EV Displayed (VS-0425-YC216) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5274 | Anti-PDGFRA Immunohistochemistry Kit | IHC | |
| VS-0525-XY5275 | Anti-Mouse PDGFRA Immunohistochemistry Kit | IHC | |
| VS-0525-XY5276 | Anti-Rat PDGFRA Immunohistochemistry Kit | IHC |
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