Anti-PSCA (clone 5F2) Recombinant Antibody Coupled Liposome (VS-1024-FY237)
CAT#: VS-1024-FY237
Anti-PSCA antibody conjugated liposomes hold significant potential in pancreatic cancer research by enabling targeted delivery of therapeutics directly to tumor cells expressing prostate stem cell antigen (PSCA). This targeted approach can enhance the efficacy of chemotherapeutics while minimizing off-target effects, potentially improving patient outcomes. Furthermore, these liposomes can serve as diagnostic tools, facilitating the early detection of pancreatic tumors through imaging techniques. Overall, the use of anti-PSCA antibody conjugated liposomes represents a promising strategy for both treatment and diagnosis in the challenging landscape of pancreatic cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Pancreatic cancer
Product Composition
- Clone
- 5F2
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This recombinant mouse monoclonal antibody has been expertly crafted to bind with high specificity to PSCA. PSCA is known to be overexpressed in various malignancies, thus making this antibody a powerful asset in cancer research and potential therapeutic applications. Through its targeted binding, researchers can effectively track PSCA expression and investigate its role in tumorigenesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PSCA
- Introduction
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
- Alternative Names
- PSCA; UNQ206; PRO232
- Full Name
- Prostate stem cell antigen
- Gene ID
- 8000
- UniProt ID
- O43653
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor
- Post Translation Modifications
- N-glycosylated. (O43653-PSCA_HUMAN)
Glycosylation at Asn31 (NX_O43653 [NX_O43653-1])
Modification sites at PhosphoSitePlus (O43653)
Glycosylation from GlyGen (O43653) 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_005663.2
- Function
- May be involved in the regulation of cell proliferation.
Has a cell-proliferation inhibition activity in vitro. PSCA_HUMAN,O43653
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
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Datasheet
MSDS
COA
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Lot Number:
- CAT
- Product Name
See other products for "PSCA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-729CL | Human Anti-PSCA Recombinant Antibody (TAB-729CL) | ELISA | Human IgG |
| TAB-259CT | Anti-Human PSCA Recombinant Antibody (10C5) | IHC, FC | Human antibody |
| TAB-260CT | Anti-Human PSCA Recombinant Antibody (6E4) | IHC, FC | Human antibody |
| TAB-261CT | Anti-Human PSCA Recombinant Antibody (6D1) | IHC, FC | Human antibody |
| TAB-259CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (10C5) | IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CT | Anti-Human PSCA Recombinant Antibody (6B8) | IHC, FC | |
| TAB-257CT | Anti-Human PSCA Recombinant Antibody (1D7) | IHC, FC | |
| TAB-258CT | Anti-Human PSCA Recombinant Antibody (2B3) | IHC, FC | |
| TAB-256CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (6B8) | IHC, FC | |
| TAB-257CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (1D7) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262CT | Humanized Anti-PSCA Recombinant Antibody (TAB-262CT) | FuncS | Humanized antibody |
| TAB-262CT-S(P) | Humanized Anti-PSCA Recombinant Antibody; scFv Fragment (TAB-262CT-S(P)) | ELISA, FC | Humanized scFv |
| TAB-262CT-F(E) | Humanized Anti-PSCA Recombinant Antibody; Fab Fragment (TAB-262CT-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1641CT | Recombinant Mouse anti-Human PSCA Monoclonal antibody (EML781) | IHC-P, WB | |
| HPAB-1900-FY | Human Anti-PSCA Recombinant Antibody (HPAB-1900-FY) | FC, Inhib, WB, ELISA | Human IgG1 |
| VS-0723-WK291 | Rabbit Anti-PSCA Recombinant Antibody (VS-0723-WK291) | ELISA, FC | Rabbit IgG |
| VS7-0425-WR699 | Mouse Anti-PSCA Recombinant Antibody (clone 5H5A7) | ICC, FC | Mouse IgG2a |
| VS7-0425-WR700 | Mouse Anti-PSCA Recombinant Antibody (clone 3F4E4) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-S(P) | Mouse Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-0074-CN-S(P)) | FC | Mouse scFv |
| HPAB-0287CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-0288CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-1309WJ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1900-FY-F(E) | Human Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-1900-FY-F(E)) | FC, Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-F(E) | Mouse Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-0074-CN-F(E)) | FC | Mouse Fab |
| HPAB-0286CQ-F(E) | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2); Fab Fragment | FC, IHC | Chimeric (mouse/human) Fab |
| HPAB-0287CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-0288CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-1900-FY-S(P) | Human Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-1900-FY-S(P)) | FC, Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY152 | Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera | ELISA, Cyt, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC192 | Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) | ELISA, FC, Cell-uptake |
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