Anti-PSCA (clone 8D11) Recombinant Antibody Coupled Liposome (VS-1024-FY293)
CAT#: VS-1024-FY293
Anti-PSCA liposomes represent a cutting-edge approach in the development of nanocarrier systems specifically engineered for targeted drug delivery aimed at cancers that express the Prostate Stem Cell Antigen (PSCA). By leveraging the unique properties of PSCA, which is frequently overexpressed in various malignant tumors such as prostate, bladder, and pancreatic cancers, these liposomes can enhance the efficacy of therapeutic agents while minimizing off-target effects. This innovative strategy not only addresses the challenges of traditional cancer treatments but also holds the potential to significantly improve patient outcomes through more precise and effective delivery of anticancer drugs.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30783/1550_B1_8_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in subset of renal tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/ihc_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_6_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56418/132825_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CAPAN-2, HeLa, OE19, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167653-PSCA/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- The use of immunoliposome-mediated targeted delivery of Cas9gRNA-IL30 offers a promising and potentially safe approach for the treatment of prostate cancer.
Product Composition
- Clone
- 8D11
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- Anti-PSCA (Prostate Stem Cell Antigen) antibodies are a type of antibody that specifically target PSCA, a glycoprotein that is typically expressed on the surface of prostate epithelial cells and is overexpressed in various types of cancers, particularly prostate cancer. The PSCA molecule has garnered attention for its potential role in cancer diagnosis and therapy because of its restricted expression pattern and association with tumor progression.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PSCA
- Introduction
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.
- Alternative Names
- PSCA; UNQ206; PRO232
- Full Name
- Prostate stem cell antigen
- Gene ID
- 8000
- UniProt ID
- O43653
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor
- Post Translation Modifications
- N-glycosylated. (O43653-PSCA_HUMAN)
Glycosylation at Asn31 (NX_O43653 [NX_O43653-1])
Modification sites at PhosphoSitePlus (O43653)
Glycosylation from GlyGen (O43653) 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_005663.2
- Function
- May be involved in the regulation of cell proliferation.
Has a cell-proliferation inhibition activity in vitro. PSCA_HUMAN,O43653
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
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Datasheet
MSDS
COA
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Lot Number:
- CAT
- Product Name
See other products for "PSCA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-729CL | Human Anti-PSCA Recombinant Antibody (TAB-729CL) | ELISA | Human IgG |
| TAB-259CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (10C5) | IHC, FC | Human antibody |
| TAB-260CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (6E4) | IHC, FC | Human antibody |
| TAB-261CT-S(P) | Anti-Human PSCA Recombinant Antibody scFv Fragment (6D1) | IHC, FC | Human antibody |
| TAB-259CT-F(E) | Anti-Human PSCA Recombinant Antibody Fab Fragment (10C5) | IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262CT | Humanized Anti-PSCA Recombinant Antibody (TAB-262CT) | FuncS | Humanized antibody |
| TAB-262CT-S(P) | Humanized Anti-PSCA Recombinant Antibody; scFv Fragment (TAB-262CT-S(P)) | ELISA, FC | Humanized scFv |
| TAB-262CT-F(E) | Humanized Anti-PSCA Recombinant Antibody; Fab Fragment (TAB-262CT-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-S(P) | Mouse Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-0074-CN-S(P)) | FC | Mouse scFv |
| HPAB-0287CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-0288CQ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8); scFv Fragment | FC, IHC | Mouse scFv |
| HPAB-1309WJ-S(P) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1900-FY-F(E) | Human Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-1900-FY-F(E)) | FC, Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0074-CN-F(E) | Mouse Anti-PSCA Recombinant Antibody; Fab Fragment (HPAB-0074-CN-F(E)) | FC | Mouse Fab |
| HPAB-0286CQ-F(E) | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2); Fab Fragment | FC, IHC | Chimeric (mouse/human) Fab |
| HPAB-0287CQ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11); Fab Fragment | FC, IHC | Mouse Fab |
| HPAB-1309WJ-F(E) | Mouse Anti-PSCA Recombinant Antibody (clone 6B8); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-1900-FY-S(P) | Human Anti-PSCA Recombinant Antibody; scFv Fragment (HPAB-1900-FY-S(P)) | FC, Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0286CQ | Human Anti-PSCA Recombinant Antibody (clone mAb 5F2) | FC, IHC, FuncS | Human IgG1 |
| HPAB-0287CQ | Mouse Anti-PSCA Recombinant Antibody (clone mAb 8D11) | FC, IHC, Cyt, FuncS | Mouse IgG2b |
| HPAB-0288CQ | Mouse Anti-PSCA Recombinant Antibody (clone mAb 6F8) | FC, IHC, FuncS | Mouse IgG2b |
| HPAB-1900-FY | Human Anti-PSCA Recombinant Antibody (HPAB-1900-FY) | FC, Inhib, WB, ELISA | Human IgG1 |
| VS-0723-WK291 | Rabbit Anti-PSCA Recombinant Antibody (VS-0723-WK291) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY152 | Mouse Anti-PSCA (clone 6B8) scFv-Fc Chimera | ELISA, Cyt, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC192 | Recombinant Anti-PSCA Vesicular Antibody, EV Displayed (VS-0425-YC192) | ELISA, FC, Cell-uptake |
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