Mouse Anti-PTPRC Recombinant Antibody (clone 9.4)
CAT#: VS3-CJ505
This product is a mouse antibody that recognizes human PTPRC (CD45).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
❯
Specifications
- Immunogen
- Native purified human CD45
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human PTPRC (CD45)
- Species Reactivity
- Human
- Clone
- 9.4
- Applications
- IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS, pH 7.3.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for one year. Do not freeze.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Immunofluorescence, Flow Cytometry.
Target
- Alternative Names
- LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
- Gene ID
- 5788
- UniProt ID
- P08575
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Heavily N- and O-glycosylated.
- Protein Refseq
- NP_002829.3; NP_563578.2
- Function
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-CJ505. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "PTPRC"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1135z | Mouse Anti-PTPRC Recombinant Antibody (clone 19C6) | WB, FC, IF, IHC | Mouse IgG2a, κ |
| HPAB-0536-FY | Human Anti-PTPRC Recombinant Antibody (HPAB-0536-FY) | Inhib, FuncS | Human IgG |
| HPAB-0537-FY | Mouse Anti-PTPRC Recombinant Antibody (HPAB-0537-FY) | FC, Block, FuncS | Mouse IgG |
| FAMAB-1649CQ | Mouse Anti-PTPRC Recombinant Antibody (clone UCH-L1) | IP, WB, FC, IHC | Mouse IgG2a |
| ZG-0562F | Mouse Anti-PTPRC Antibody (clone 2B11/PD7/26) | IHC-P, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242LC | Anti-Human PTPRC Recombinant Antibody (VHQ/humV1) | Inhib | Humanized antibody |
| TAB-243LC | Anti-Human PTPRC Recombinant Antibody (VHQ/humV2 ) | Inhib | Humanized antibody |
| TAB-244LC | Anti-Human PTPRC Recombinant Antibody (VHE-N73D/humV1 ) | Inhib | Humanized antibody |
| TAB-240LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHE/humV1) | ELISA, FC | Humanized antibody |
| TAB-241LC-F(E) | Anti-Human PTPRC Recombinant Antibody Fab Fragment (VHE/humV2) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245LC | Human Anti-PTPRC Recombinant Antibody (TAB-245LC) | ELISA, FC | Human IgG2, κ |
| TAB-246LC | Human Anti-PTPRC Recombinant Antibody (TAB-246LC) | ELISA, FC | Human IgG2, κ |
| TAB-247LC | Human Anti-PTPRC Recombinant Antibody (TAB-247LC) | ELISA, FC | Human IgG2, κ |
| TAB-248LC | Human Anti-PTPRC Recombinant Antibody (TAB-248LC) | ELISA, FC | Human IgG2, κ |
| TAB-249LC | Human Anti-PTPRC Recombinant Antibody (TAB-249LC) | ELISA, FC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0466MZ | Chicken Anti-PTPRC Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1895CQ | Recombinant Mouse Anti-PTPRC Antibody (HI30) | WB, IP, IHC-Fr, FuncS, ICC, FC, IHC-P, BL | IgG1 |
| NEUT-1896CQ | Recombinant Mouse Anti-Ptprc Antibody (104-2) | FC, IP, BL, IHC-Fr, ICC, IF | IgG2a, κ |
| NEUT-1897CQ | Recombinant Rat Anti-Ptprc Antibody (MAB0822) | BL, FC, IP, WB | IgG2 |
| NEUT-1898CQ | Recombinant Rat Anti-Ptprc Antibody (RA3-6B2) | FC, IHC-Fr, IHC-P, IP, WB, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2933 | Hi-Affi™ Recombinant Rabbit Anti-PTPRC Monoclonal Antibody (DS2933AB) | IP, WB | IgG |
| MOR-0089-FY | Rabbit Anti-PTPRC Recombinant Antibody (clone AFY0060) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-S(P) | Rabbit Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0365-CN-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0366-CN-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0366-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0258-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0258-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0536-FY-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0536-FY-S(P)) | Inhib, FuncS | Human scFv |
| HPAB-0537-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0537-FY-S(P)) | FC, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-F(E) | Rabbit Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0365-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-M0191-YC-F(E) | Human Anti-PTPRC Recombinant Antibody (clone M/YC-14); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-1058-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-1058-FY-S(P)) | ELISA, Neut | scFv |
| HPAB-0536-FY-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0536-FY-F(E)) | Inhib, FuncS | Human Fab |
| HPAB-0537-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0537-FY-F(E)) | FC, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-023CN | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4) | FC, IF | Mouse IgG1, κ |
| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY220 | AbPlus™ Anti-PTPRC Magnetic Beads (YTH54.12) | IP, Protein Purification | |
| VS-0724-YC1181 | AbPlus™ Anti-PTPRC Magnetic Beads (VS-0724-YC1181) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY98 | Mouse Anti-NHP PTPRC Recombinant Antibody (clone MEM55) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY185 | CytoStream™ Rat Anti-PTPRC Recombinant Antibody (clone 30-F11) | FC | Rat IgG2b, kappa |
| VS-0225-XY186 | CytoStream™ Mouse Anti-PTPRC Recombinant Antibody (clone OX-33) | FC | Mouse IgG1, kappa |
| VS13-YC960 | CytoStream™ Rabbit Anti-PTPRC Recombinant Antibody (VS13-YC960) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY86 | Human Anti-PTPRC (clone VHE-N73D/humV1) scFv-Fc Chimera | IF, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC529 | Recombinant Anti-PTPRC Vesicular Antibody, EV Displayed (VS-0425-YC529) | ELISA, FC, Neut, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, SPR, Inhib, FuncS
Application: WB, ELISA, IF
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: Neut, ELISA, FuncS
Application: ELISA, WB
Application: ELISA, Vaccine, FuncS
Application: ELISA, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
