Mouse Anti-ROR1 Recombinant Antibody Hexamer (VS-0924-YC149), CDC Enhanced

CAT#: VS-0924-YC149

The product is a hexameric mouse anti-ROR1 antibody with enhanced complement-dependent cytotoxicity (CDC) activity. This IgG1 antibody, which targets human ROR1, features hexamerization-enhancing mutations. These mutations promote hexamer formation, facilitating optimal C1q binding and thereby boosting CDC efficacy.

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, CACO-2, HHSteC, HSkMC, NTERA-2)

Specifications

  • Host Species
  • Mouse
  • Type
  • Antibody hexamer
  • Specificity
  • Human ROR1
  • Species Reactivity
  • Human
  • Molecule Class
  • ~ 900 kDa
  • Applications
  • ELISA, FC, CDC
  • Conjugate
  • None
  • Related Disease
  • Lymphomas, leukemia, and solid tumors such as breast, colon, lung, and kidney tumors

Product Property

  • Clonality
  • Monoclonal
  • Purification
  • Protein G purified
  • Purity
  • >95% determined as SDS-PAGE and SEC-HPLC
  • Aggregation
  • <5%
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; dJ537F10.1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1
  • Long Name
  • Receptor Tyrosine Kinase Like Orphan Receptor 1
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