Recombinant Anti-ROR1 (AA 132-153 x AA 904-918) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC155)

• Host Animal 1
• Human

• Host Animal 2
• Mouse

• Specificity
• Human ROR1

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• aa 132-153, VATNGKEVVSSTGVLFVKFGPC

• Epitope 2
• aa 904-918, NKSQKPYKIDSKQAS

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• inactive tyrosine-protein kinase transmembrane receptor ROR1

• Introduction
• This gene encodes a tropomyosin receptor kinase A that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

• Alternative Names
• NTRKR1; dJ537F10.1

• Gene ID
• 4919

• UniProt ID
• Q01973

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