Recombinant Anti-ROR1 (AA 132-153 x AA 904-918) Biparatopic Antibody, Tandem scFv

CAT#: VS-0525-YC155

Recombinant Anti-ROR1 (AA 132-153 x AA 904-918) Biparatopic Antibody, Tandem scFv is a biparatopic antibody (bpAb) designed for dual epitope binding to ROR1. This construct features tandem scFv arms. These arms exhibit simultaneous, high-affinity binding to amino acids 132-153 (VATNGKEVVSSTGVLFVKFGPC) and 904-918 (NKSQKPYKIDSKQAS).

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, CACO-2, HHSteC, HSkMC, NTERA-2)

Specifications

  • Host Animal 1
  • Human
  • Host Animal 2
  • Mouse
  • Specificity
  • Human ROR1
  • Species Reactivity
  • Human
  • Type
  • Tandem scFv
  • Valency
  • 1 + 1
  • Epitope 1
  • aa 132-153, VATNGKEVVSSTGVLFVKFGPC
  • Epitope 2
  • aa 904-918, NKSQKPYKIDSKQAS
  • Purity
  • >90%
  • Purification
  • Affinity purified
  • Applications
  • ELISA, FC
  • Concentration
  • Lot specific
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
  • Long Name
  • inactive tyrosine-protein kinase transmembrane receptor ROR1

Target

  • Introduction
  • This gene encodes a tropomyosin receptor kinase A that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • NTRKR1; dJ537F10.1
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