Human Anti-ROR1 scFv-Fc Chimera (VS-0125-FY36) (CAT#: VS-0125-FY36)
The Anti-ROR1 scFv-Fc is a therapeutic construct that combines a single-chain variable fragment (scFv) with an Fc region to target the ROR1 antigen on tumor cells. The scFv retains the antigen-binding ability of full-length antibodies while being smaller, which facilitates better tissue penetration. The Fc region enhances the construct's stability, provides prolonged circulation time, and allows engagement with immune effector cells to boost the immune response. This construct can be utilized for therapeutic applications such as antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic drugs to cancer cells. Additionally, the Fc portion can help modulate the immune system to enhance anti-tumor activity. Incorporating alternative linkers, like sulfone linkers, can further improve stability and expand the valency of the conjugates, thus optimizing their efficacy in vivo.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, CACO-2, HHSteC, HSkMC, NTERA-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185483-ROR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185483-ROR1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Applications
- Antibody-dependent cellular cytotoxicity, Complement-dependent cytolysis
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-scFv-Fc construct targeting ROR1 has multiple potential functions. Firstly, the scFv domain specifically targets cancer cells, allowing it to uniquely recognize the ROR1 antigen for specific tumor localization. Additionally, the Fc region of the construct can activate effector functions by engaging with Fc receptors, potentially triggering antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Furthermore, the inclusion of the Fc portion helps enhance the stability of the construct, improve its pharmacokinetic properties, and extend its circulation time in the bloodstream.
Target
- Alternative Names
- Receptor Tyrosine Kinase Like Orphan Receptor 1; Neurotrophic Tyrosine Kinase, Receptor-Related 1; NTRKR1; Inactive Tyrosine-Protein Kinase Transmembrane Receptor ROR1; EC 2.7.10.1; DJ537F10.1
- Gene ID
- 4919
- UniProt ID
- Q01973
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
- Cellular Localization
- Cell projection, Membrane
- Protein Refseq
- NP_001077061.1; NP_005003.2
- Function
- Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo.
Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling.
In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336CT | Mouse Anti-ROR1 Recombinant Antibody (TAB-336CT) | WB, ELISA, FC | Mouse IgG1 |
| TAB-337CT | Mouse Anti-ROR1 Recombinant Antibody (TAB-337CT) | WB, FC, Cyt | Mouse IgG1 |
| TAB-338CT | Mouse Anti-ROR1 Recombinant Antibody (TAB-338CT) | WB, FC, Cyt | Mouse IgG1 |
| TAB-336CT-S(P) | Mouse Anti-ROR1 Recombinant Antibody; scFv Fragment (TAB-336CT-S(P)) | WB, ELISA, FC | Mouse scFv |
| TAB-337CT-S(P) | Mouse Anti-ROR1 Recombinant Antibody; scFv Fragment (TAB-337CT-S(P)) | WB, ELISA, FC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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