Mouse Anti-SDC1 Recombinant Antibody (VS-1225-XY233)
CAT#: VS-1225-XY233
This antibody is validated for SDC1 detection in ELISA, WB, and IHC. It offers stable binding affinity, supporting long-term experimental reproducibility.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
Normal Tissue
Figure 4 Testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- IHC
- Specificity
- SDC1
- Target
- SDC1
- Species Reactivity
- Human
- Type
- Mouse IgG1
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Protein A purified
- Format
- Liquid
- Buffer
- PBS with 50% glycerol, 1% BSA
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- Syndecan-1 (SDC1), or CD138, is a transmembrane proteoglycan expressed on plasma cells, epithelial cells, and stromal cells. It binds growth factors, chemokines, and extracellular matrix molecules, regulating cell adhesion, signaling, and angiogenesis. CD138 is highly expressed on malignant plasma cells in multiple myeloma (MM) and is a diagnostic marker for the disease. It is targeted by monoclonal antibodies (elotuzumab) and ADCs, which induce ADCC and inhibit signaling pathways critical for MM cell survival. CD138 targeting is integral to MM treatment, particularly in combination with other agents like proteasome inhibitors.
- Alternative Names
- CD138, SDC, SYND1, syndecan
- Gene ID
- 6382
- UniProt ID
- P18827
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0324-CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0324-CN-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0326-CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0326-CN-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0324-CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0324-CN-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NS-086CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-086CN-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
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| NS-087CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-087CN-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
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| NS-086CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (NS-086CN-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2546LY-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-2546LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY6404 | Anti-Rat SDC1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-1225-XY221 | Mouse Anti-SDC1 Recombinant Antibody (VS-1225-XY221) | IHC, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY222 | Mouse Anti-SDC1 Recombinant Antibody (VS-1225-XY222) | IHC, ICC, IF, ELISA | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-XY223 | Mouse Anti-SDC1 Recombinant Antibody (VS-1225-XY223) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| VS-1225-XY224 | Mouse Anti-SDC1 Recombinant Antibody (VS-1225-XY224) | ELISA | Rabbit IgG |
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