Mouse Anti-SHC1 Recombinant Antibody (clone 2F7C7) (CAT#: VS7-0425-WR852)

This product is a mouse IgG1 antibody that binds to human SHC1. The antibody 2F7C7 recognizes specific amino acid domain of human SHC1 (AA: 385-495). It can be used for WB, ICC, and FC assays. It cross reacts with mouse.

Specific Inquiry
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  • Conjugation:

  • Endotoxin:

  • Purity:

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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Endotoxin :
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We require custom production
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • Recombinant human SHC1 (AA: 385-495) fragment expressed in E. Coli.
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human SHC1
  • Species Reactivity
  • Human, Mouse
  • Clone
  • 2F7C7
  • Molecule Class
  • Adapter Protein
  • Applications
  • WB, ICC, FC
  • Conjugate
  • Unconjugated

Product Property

  • Clonality
  • Monoclonal
  • Purity
  • >95% as determined by SDS-PAGE and SEC-HPLC analysis
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • 0.05% sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • Western Blot: 1:500 - 1:2000
    Immunocytochemistry: 1:200 - 1:1000
    Flow Cytometry: 1:200 - 1:400
    Enzyme-linked Immunosorbent Assay: 1:10000

Target

  • Alternative Names
  • SHC1; SHCA; Src Homology 2 Domain-Containing-Transforming Protein C1; SHC-Transforming Protein A; SHC; SH2 Domain Protein C1; SHC-Transforming Protein 1
  • Long Name
  • SHC adaptor protein 1
  • Cellular Localization
  • Cell junction; Cytoplasm; Mitochondrion
  • Post Translation Modifications
  • Acetylation; Phosphoprotein
  • Function
  • Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity).; Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis

Recommended Products

Reconstitution Buffer

Recommended Dilution Buffer

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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