Mouse Anti-TACR1 Recombinant Antibody (clone 11) (CAT#: FAMAB-0217JF)
Recombinant monoclonal antibody specially binds to the ligand-binding domain of the neurokinin 1 receptor for the neuropeptide substance P. This mouse anti-neurokinin 1 receptor antibody (clone 11) can be useful to treat patients with inflammatory conditions affecting peripheral organs, sunch as skin or eye allergic reactions, arthritis and bronchial asthma.
Specific Inquiry
IHC
Figure 1 Immunohistochemistry observed that the expression levels of TACR1 protein in the articular cartilage of child KBD finger.
These results support the implication of TACR1 in the development of KBD.
Wen, Y., Hao, J., Guo, X., Xiao, X., Wu, C., Wang, S., ... & Tian, Q. (2015). SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. Journal of biomedical informatics, 57, 38-41.
WB
Figure 2 TACR1 overexpression reversed inhibitory effect of RMRP depletion on cell progression by activating ERK signals in neuroblastoma cells.
RMRP exerted its oncogenic effects by regulating TACR1 in neuroblastoma cells.
Pan, J., Zhang, D., Zhang, J., Qin, P., & Wang, J. (2019). LncRNA RMRP silence curbs neonatal neuroblastoma progression by regulating microRNA-206/tachykinin-1 receptor axis via inactivating extracellular signal-regulated kinases. Cancer biology & therapy, 20(5), 653-665.
ELISA
Figure 3 Inhibition of TACR1 and ERK1/2 signal abated RMRP-mediated pro-proliferation effect in neuroblastoma cells.
TACR1 inhibitor fosaprepitant and ERK1/2 kinase inhibitor PD98059 were used to further testify our conclusion that oncogenic effect of RMRP was realized by regulating TACR1.
Pan, J., Zhang, D., Zhang, J., Qin, P., & Wang, J. (2019). LncRNA RMRP silence curbs neonatal neuroblastoma progression by regulating microRNA-206/tachykinin-1 receptor axis via inactivating extracellular signal-regulated kinases. Cancer biology & therapy, 20(5), 653-665.
Specifications
- Immunogen
- PS5 (sequence HQSKELLRLGS) conjugate emulsified with Freund's complete adjuvant
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Rat TACR1
- Species Reactivity
- Rat
- Clone
- 11
- Applications
- WB, ELISA, IHC
- Related Disease
- Schizophrenia, Migraine, Fibromyalgia
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The TACR1 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2516z | Mouse Anti-TACR1 Recombinant Antibody (clone 35G6) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| FAMAB-0216JF | Mouse Anti-TACR1 Recombinant Antibody (clone 12) | WB, ELISA, IHC | Mouse IgG2a |
| FAMAB-0218JF | Mouse Anti-TACR1 Recombinant Antibody (clone 6) | WB, IHC | Mouse IgG2a |
| FAMAB-0219JF | Mouse Anti-TACR1 Recombinant Antibody (clone 17) | WB, Inhib | Mouse IgG1 |
| VS3-FY1422 | Recombinant Rabbit Anti-TACR1 Antibody (clone R05-3D1) | WB, IP | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3490 | Hi-Affi™ Recombinant Rabbit Anti-TACR1 Monoclonal Antibody (DS3490AB) | IP, WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0216JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 12); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0217JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 11); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0218JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 6); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0219JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 17); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0216JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 12); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0217JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 11); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0218JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 6); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0219JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 17); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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