Camelid Anti-TIGIT Recombinant Antibody (VS-1125-XY983)
CAT#: VS-1125-XY983
This TIGIT recombinant antibody is employed in cell therapy, serving as a reliable resource for the advancement of cell treatment approaches. Moreover, it is used in companion diagnostics to aid in relevant medical testing procedures.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181847-TIGIT
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Specifications
- Host Animal
- Camelid
- Applications
- IHC, ICC, IF, FC, ELISA
- Specificity
- TIGIT
- Target
- TIGIT
- Species Reactivity
- Human
- Type
- Camelid scFv
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Affinity chromatography
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No Preservative
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an immune checkpoint receptor expressed on T cells, NK cells, and Tregs. It binds ligands CD155 (PVR) and CD112 (Nectin-2) on tumor cells or APCs, inhibiting T cell and NK cell cytotoxicity and promoting immune evasion. Overexpressed in various cancers (melanoma, NSCLC, RCC) and associated with poor prognosis, TIGIT is a promising next-generation checkpoint target. Inhibitors (tiragolumab, vibostolimab) are being tested alone or in combination with PD-1/PD-L1 blockers, showing synergistic anti-tumor activity by simultaneously targeting multiple immune checkpoints.
- Alternative Names
- VSIG9, VSTM3, WUCAM
- Gene ID
- 201633
- UniProt ID
- Q495A1
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0279CL | Hamster Anti-TIGIT Recombinant Antibody (TAB-0279CL) | FuncS | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0280CL | Hamster Anti-TIGIT Recombinant Antibody (TAB-0280CL) | Inhib, WB, FC | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0279CL-S(P) | Hamster Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-0279CL-S(P)) | ELISA, FuncS, FC | Hamster scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0280CL-S(P) | Hamster Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-0280CL-S(P)) | ELISA, FuncS, FC | Hamster scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0279CL-F(E) | Hamster Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-0279CL-F(E)) | ELISA, FuncS, FC | Hamster Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-662CT | Humanized Anti-TIGIT Recombinant Antibody (TAB-662CT) | WB, ELISA, FC, Inhib | Humanized IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-663CT | Humanized Anti-TIGIT Recombinant Antibody (TAB-663CT) | WB, ELISA, FC, Inhib | Humanized IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-662CT-S(P) | Humanized Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-662CT-S(P)) | WB, ELISA, FC, Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-663CT-S(P) | Humanized Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-663CT-S(P)) | WB, ELISA, FC, Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-662CT-F(E) | Humanized Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-662CT-F(E)) | WB, ELISA, FC, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2025CQ | Mouse Anti-TIGIT Recombinant Antibody (clone 1G9) | FC, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2026CQ | Mouse Anti-TIGIT Recombinant Antibody (clone CBL382) | Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2027CQ | Mouse Anti-TIGIT Recombinant Antibody (clone CBL383) | Block, CyTOF, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0019CQ) | ELISA, FC, Inhib | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0020CQ) | ELISA, FC, Inhib | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0021CQ) | ELISA, FC, FuncS | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022CQ | Human Anti-TIGIT Recombinant Antibody (HPAB-0022CQ) | ELISA, FC, Block, FuncS | Humanized IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023CQ | Human Anti-TIGIT Recombinant Antibody (HPAB-0023CQ) | ELISA, FC, Block, FuncS | Humanized IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019CQ-S(P) | Mouse Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0019CQ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020CQ-S(P) | Mouse Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0020CQ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021CQ-S(P) | Mouse Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0021CQ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022CQ-S(P) | Human Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0022CQ-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023CQ-S(P) | Human Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0023CQ-S(P)) | ELISA, FC, Block | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019CQ-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-0019CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020CQ-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-0020CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021CQ-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-0021CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022CQ-F(E) | Human Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-0022CQ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023CQ-F(E) | Human Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-0023CQ-F(E)) | ELISA, FC, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY41 | Hamster Anti-Tigit Agonistic Antibody (clone 4D4) | FC, Agonistic assays | Hamster IgG, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY42 | Rabbit Anti-Tigit Agonistic Antibody (VS-0724-XY42) | FC, Agonistic assays | Rabbit IgG, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY209 | CytoStream™ Mouse Anti-TIGIT Recombinant Antibody (VS-0225-XY209) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY210 | CytoStream™ Rat Anti-TIGIT Recombinant Antibody (VS-0225-XY210) | FC | Rat IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY8 | Human Anti-TIGIT scFv-Fc Chimera (VS-0325-FY8) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC105 | Recombinant Anti-TIGIT Vesicular Antibody, EV Displayed (VS-0425-YC105) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7258 | Anti-TIGIT Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC329 | SmartAb™ Recombinant Anti-TIGIT pH-dependent Antibody (VS-0825-YC329) | WB, ELISA, FC, Inhib | Human IgG4 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY978 | Rabbit Anti-TIGIT Recombinant Antibody (VS-1125-XY978) | WB, IHC, ICC, IF, ELISA, SPR | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY979 | Rabbit Anti-TIGIT Recombinant Antibody (VS-1125-XY979) | FC, SPR | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY980 | Rabbit Anti-TIGIT Recombinant Antibody (VS-1125-XY980) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY981 | Mouse Anti-TIGIT Recombinant Antibody (VS-1125-XY981) | FC, ELISA | Mouse IgG1, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1125-XY982 | Hamster Anti-TIGIT Recombinant Antibody (VS-1125-XY982) | FC | Hamster IgG, kappa |
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