Anti-TIMP1 (clone HuCAL) Recombinant Antibody Coupled Liposome (VS-1024-FY132) (CAT#: VS-1024-FY132)
Lipid nanoparticles bound to anti-TIMP-1 antibodies show potential applications in glioma research. These nanoparticles can help target glioma cells, improving the effectiveness of treatment and potentially reducing side effects. By binding to anti-TIMP-1 antibodies, these lipid nanoparticles can more precisely locate and attack tumor cells, thereby enhancing anti-tumor activity.
More Infomation
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22360/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22360/if_selected.jpg
Figure 2 IHC staining of human prostate
(Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/ihc_selected.jpg
(Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/ihc_selected.jpg
Figure 3 Kidney
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_7_5.jpg
Figure 4 Prostate
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_2_5.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_2_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102265-TIMP1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102265-TIMP1
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- HuCAL
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been engineered to specifically recognize and bind to human Tissue Inhibitor of Metalloproteinases 1 (TIMP1). Monoclonal antibodies are laboratory-made molecules that can mimic the immune system's ability to fight off harmful pathogens such as viruses. In this case, the antibody is designed to target TIMP1, a key regulatory protein involved in the inhibition of metalloproteinases, which are enzymes that degrade extracellular matrix proteins.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TIMP1
- Introduction
- This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
- Alternative Names
- TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPA
- Full Name
- TIMP Metallopeptidase Inhibitor 1
- Gene ID
- 7076
- UniProt ID
- P01033
- Cellular Localization
- Secreted
Downloads
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Human Antibody Products
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MHC Tetramer Products for Cancer
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-683CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-683CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-684CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-28) | ELISA, BL | Human antibody |
| TAB-685CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-1) | ELISA, BL | Human antibody |
| TAB-686CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-27) | ELISA, BL | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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