Anti-TIMP1 (clone HuCAL) Recombinant Antibody Coupled Liposome (VS-1024-FY132)
CAT#: VS-1024-FY132
Lipid nanoparticles bound to anti-TIMP-1 antibodies show potential applications in glioma research. These nanoparticles can help target glioma cells, improving the effectiveness of treatment and potentially reducing side effects. By binding to anti-TIMP-1 antibodies, these lipid nanoparticles can more precisely locate and attack tumor cells, thereby enhancing anti-tumor activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22360/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/ihc_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_7_5.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_2_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102265-TIMP1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- HuCAL
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been engineered to specifically recognize and bind to human Tissue Inhibitor of Metalloproteinases 1 (TIMP1). Monoclonal antibodies are laboratory-made molecules that can mimic the immune system's ability to fight off harmful pathogens such as viruses. In this case, the antibody is designed to target TIMP1, a key regulatory protein involved in the inhibition of metalloproteinases, which are enzymes that degrade extracellular matrix proteins.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TIMP1
- Introduction
- This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
- Alternative Names
- TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPA
- Full Name
- TIMP Metallopeptidase Inhibitor 1
- Gene ID
- 7076
- UniProt ID
- P01033
- Cellular Localization
- Secreted
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone HuCAL"
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- Product Name
See other products for "TIMP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-683CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-684CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-28) | ELISA, BL | Human antibody |
| TAB-685CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-1) | ELISA, BL | Human antibody |
| TAB-686CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-27) | ELISA, BL | Human antibody |
| TAB-683CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3575 | Rabbit Anti-TIMP1 Recombinant Antibody (clone DS3575AB) | WB | Rabbit IgG |
| MOR-4458 | Rabbit Anti-TIMP1 Recombinant Antibody (clone SI552DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1976 | PE-B7/Human TIMP1 (APFEPLASGIL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-S(P) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); scFv Fragment | ELISA | Human scFv |
| HPAB-0192-WJ-S(P) | Human Anti-TIMP1 Recombinant Antibody; scFv Fragment (HPAB-0192-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-F(E) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); Fab Fragment | ELISA | Human Fab |
| HPAB-0192-WJ-F(E) | Human Anti-TIMP1 Recombinant Antibody; Fab Fragment (HPAB-0192-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0192-WJ | Human Anti-TIMP1 Recombinant Antibody (HPAB-0192-WJ) | ELISA | Human IgE |
| ZG-0125C | Mouse Anti-TIMP1 Recombinant Antibody (clone PT2236) | IHC-P, IF | Mouse IgG |
| ZG-0126C | Mouse Anti-TIMP1 Recombinant Antibody (clone ABT-TIMP1) | IHC-P, IF | Mouse IgG |
| ZG-0154U | Mouse Anti-Timp1 Recombinant Antibody (clone 4A2B1) | ELISA, IHC | Mouse IgG1 |
| VS3-XY1527 | Mouse Anti-TIMP1 Recombinant Antibody (clone 4C2) | WB, IHC, ICC, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY147 | Human Anti-TIMP1 (clone mab1) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7268 | Anti-TIMP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7269 | Anti-Mouse TIMP1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC312 | Recombinant Anti-TIMP1 Eliminating Antibody, pH-Sensitive (MS-BW-27 var.) | Antigen-Sweeping In Vivo. | Human IgG |
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