TIMP1

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For Research Use Only. Not For Clinical Use.


Background

Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Fibroblasts, Langerhans cells, Smooth muscle cells, Leydig cells, Macrophages, Peritubular cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)

Interaction

Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.

Molecular function

Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

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