Afuco™ Anti-TNFRSF10A ADCC Recombinant Antibody (Mapatumumab), ADCC Enhanced (CAT#: AFC-TAB-H48)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human TNFRSF10A. Mapatumumab (HGS-ETR1) is an experimental human monoclonal antibody for the treatment of cancer.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/877_F10_1_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/if_selected.jpg
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/ihc_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50958/834_F10_1_red_green.jpg
Figure 5 Small intestine
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_5_2.jpg
Figure 6 Colon
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_9_3.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54475/130222_A_7_5.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104689-TNFRSF10A
Specifications
- Host Species
- Human
- Derivation
- human
- Type
- ADCC enhanced antibody
- Specificity
- TNFRSF10A(tumor necrosis factor receptor (TNFR) superfamily member 10A, death receptor 4, DR4, TNF-related apoptosis-inducing ligand receptor 1, TRAILR1, TRAIL-R1, TR-1, CD261) agonistic antibody [Homo sapiens]
- Species Reactivity
- Human
- Clone
- Mapatumumab
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Mapatumumab
- Related Disease
- Colorectal cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Mapatumumab; 658052-09-6; HGS-ETR1; TRM-1; HGS-ETR1; HGS-ETR1; TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4
- Gene ID
- 8797
- UniProt ID
- O00220
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "mapatumumab"
Anti-Human TNFRSF10A Recombinant Antibody (Mapatumumab)Recombinant human antibody to Human TNFRSF10A. Mapatumumab (HGS-ETR1) is an experimental human monoclonal antibody for the treatment of cancer.
See other products for "TNFRSF10A"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H48 | Anti-Human TNFRSF10A Recombinant Antibody (Mapatumumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 |
| TAB-160CQ | Human Anti-TNFRSF10A Recombinant Antibody (TAB-160CQ) | ELISA, FC | Human IgG |
| TAB-160CQ-S(P) | Human Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (TAB-160CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-160CQ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (TAB-160CQ-F(E)) | ELISA, FC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-161CQ | Anti-Human TNFRSF10A Recombinant Antibody (4H6.17.8) | FC, ELISA, Block | |
| TAB-162CQ | Anti-Human TNFRSF10A Recombinant Antibody (4E7.24.3) | FC, ELISA, Block | |
| TAB-161CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4H6.17.8) | ELISA, FC, BL | |
| TAB-162CQ-S(P) | Anti-Human TNFRSF10A Recombinant Antibody scFv Fragment (4E7.24.3) | ELISA, FC, BL | |
| TAB-161CQ-F(E) | Anti-Human TNFRSF10A Recombinant Antibody Fab Fragment (4H6.17.8) | ELISA, FC, BL |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2090MZ | Recombinant Mouse Anti-Human TNFRSF10A Antibody (clone 43B353) | WB | Mouse antibody |
| HPAB-0460-WJ | Mouse Anti-TNFRSF10A Recombinant Antibody (HPAB-0460-WJ) | ELISA, FuncS | Mouse IgG1, λ |
| HPAB-0461-WJ | Human Anti-TNFRSF10A Recombinant Antibody (HPAB-0461-WJ) | ELISA, FuncS | Humanized IgG |
| HPAB-0412-YJ | Mouse Anti-TNFRSF10A Recombinant Antibody (HPAB-0412-YJ) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0413-YJ | Human Anti-TNFRSF10A Recombinant Antibody (HPAB-0413-YJ) | ELISA, FuncS, FC | Chimeric (Mouse/Human) IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2109CQ | Mouse Anti-TNFRSF10A Recombinant Antibody (clone 32A1380) | FC, IHC, Neut, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4466 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI560DS) | ELISA | Rabbit IgG |
| MOR-4467 | Rabbit Anti-TNFRSF10A Recombinant Antibody (clone SI561DS) | FC | Rabbit IgG |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0627-CN | Camelid Anti-TNFRSF10A Recombinant Antibody (HPAB-0627-CN) | ELISA | VHH |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0460-WJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0460-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0461-WJ-S(P) | Human Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0461-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0412-YJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0412-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0413-YJ-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody; scFv Fragment (HPAB-0413-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-S0144-YC-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone ch4H6); scFv Fragment | ELISA, FC, Block, ADCC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0412-YJ-F(E) | Mouse Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0412-YJ-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0413-YJ-F(E) | Human Anti-TNFRSF10A Recombinant Antibody; Fab Fragment (HPAB-0413-YJ-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-1616-FY-S(P) | Mouse Anti-TNFRSF10A Recombinant Antibody (clone mAY4); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-1617-FY-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone hAY4); Fab Fragment | WB, ELISA | Humanized Fab |
| HPAB-1618-FY-S(P) | Human Anti-TNFRSF10A Recombinant Antibody (clone Hvh3); Fab Fragment | WB, ELISA | Human Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-TAB-H48. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.