Mouse Anti-TTR Recombinant Antibody (clone 14G8) (CAT#: HPAB-0642LY)
This product is an antibody that recognizes TTR. The antibody 14G8 can be used for immunoassay techniques such as: WB, FC, ELISA.
Specific Inquiry
WB
Figure 1 Characterization of 14G8 mAb by Western blot analysis.
Native TTR (TTR) and pH4-TTR (F) were separated by non-denaturing SDS-PAGE and Western blotted with 14G8 mAb. pH4-TTR migrated as a 15 kDa monomer and a 32 kDa non-native dimer.
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
FuncS
Figure 2 TTR mAb-dependent phagocytosis.
All four anti-misTTR antibodies increased uptake of aggregated pHrodo-ATTR V30M in a dose-dependent fashion as measured by pHrodo-positive THP-1 cells. In contrast, no uptake was observed in cells treated with an isotype control IgG and no fluorescence was detected in untreated cells (red circle).
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
IHC
Figure 3 Staining of TTR by the 14G8 mis-TTR mAb.
14G8 did stain intracellular TTR present in normal pancreatic α-cells.
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
Specifications
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human TTR
- Species Reactivity
- Human
- Clone
- 14G8
- Applications
- WB, FuncS, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunohistochemistry and Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin;
- Gene ID
- 7276
- UniProt ID
- P02766
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 14G8"
See other products for "TTR"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2498-sdAb | Recombinant Anti-human TTR VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| HPAB-0483-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (clone 1) | ELISA | Camel VHH |
| HPAB-0484-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (clone 5) | ELISA | Camel VHH |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-128 | Mouse Anti-TTR Recombinant Antibody (clone 39-44); scFv Fragment | WB, Block | Mouse scFv |
| HPAB-0642LY-S(P) | Mouse Anti-TTR Recombinant Antibody (clone 14G8); scfv Fragment | WB, FC, ELISA | Mouse scfv |
| HPAB-0643LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v1); scfv Fragment | WB, FC, ELISA | Humanized scfv |
| HPAB-0644LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v2); scfv Fragment | WB, FC, ELISA | Humanized scfv |
| HPAB-0645LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v3); scfv Fragment | WB, FC, ELISA | Humanized scfv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0423CL | Human Anti-TTR Recombinant Antibody (TAB-0423CL) | ELISA, DB, WB, IF | Human IgG |
| TAB-0423CL-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (TAB-0423CL-S(P)) | ELISA, DB, WB, IF | Human scFv |
| TAB-0423CL-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (TAB-0423CL-F(E)) | ELISA, DB, WB, IF | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-166CQ | Mouse Anti-TTR Recombinant Antibody (TAB-166CQ) | ELISA, WB | Mouse IgG1, κ |
| TAB-165CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-165CQ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-166CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-166CQ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-165CQ-F(E) | Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-165CQ-F(E)) | ELISA, WB | Mouse Fab |
| TAB-166CQ-F(E) | Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-166CQ-F(E)) | ELISA, WB | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1684CT | Recombinant Mouse anti-Human TTR Monoclonal antibody (20F2) | IP, WB | |
| VS3-QX1172 | Mouse Anti-TTR Recombinant Antibody (clone 10F7-2E8-5E8) | WB, IHC | Mouse IgG1 |
| VS3-QX1173 | Mouse Anti-TTR Recombinant Antibody (clone 1F6-9A9-6A5) | WB, IHC | Mouse IgG1 |
| VS3-QX1174 | Mouse Anti-TTR Recombinant Antibody (clone 1F7-4F7-2H10) | WB, IHC | Mouse IgG1 |
| VS3-QX1175 | Mouse Anti-TTR Recombinant Antibody (clone 3B10-9F2-3H3) | WB, IHC | Mouse IgG1 |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0600MZ | Chicken Anti-Transthyretin Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3717 | Rabbit Anti-TTR Recombinant Antibody (clone DS3717AB) | FC, ICC, IHC-P, IP, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0108-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0108-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0109-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0109-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0110-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0110-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0111-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0111-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0642LY-F(E) | Mouse Anti-TTR Recombinant Antibody (clone 14G8); Fab Fragment | WB, FC, ELISA | Mouse Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-0642LY. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.