Anti-VEGFA (clone B20-4) Recombinant Antibody Coupled Liposome (VS-1024-FY276) (CAT#: VS-1024-FY276)
Anti-VEGF liposomes are a nano-drug delivery system that can effectively deliver anti-VEGF (vascular endothelial growth factor) drugs to tumor tissues, utilizing the enhanced permeability and retention (EPR) effect characteristic of tumors.
Anti-VEGF antibody conjugated liposomes hold significant potential in research for metastatic fibrosarcoma by enhancing targeted delivery of therapeutic agents directly to tumor sites, thereby minimizing systemic side effects. The conjugation with anti-VEGF antibodies allows these liposomes to preferentially bind to vascular endothelial growth factor (VEGF) receptors that are often overexpressed in tumor vasculature, improving uptake by cancer cells. This targeted approach can facilitate the efficient release of chemotherapeutics or RNA-based therapies, potentially leading to improved treatment outcomes. Additionally, studying these liposomes can provide insights into tumor microenvironment interactions and the mechanisms of resistance, ultimately contributing to more effective cancer therapies.
More Infomation
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_7_5.jpg
(Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_7_5.jpg
Figure 2 Thyroid gland
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_1_5.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_1_5.jpg
Figure 3 Colon
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_3.jpg
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_3.jpg
Figure 4 Liver
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_8_4.jpg
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_8_4.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_9_5.jpg
(Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_9_5.jpg
Figure 6 Testis
(Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_5_6.jpg
(Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_5_6.jpg
Figure 7 Lymph node
(Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_8.jpg
(Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000112715-VEGFA
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000112715-VEGFA
Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112715-VEGFA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112715-VEGFA
Specifications
- Potential Clinical Applications
- Colorectal cancer, Metastatic fbrosarcoma, Neovascular age-related macular degeneration (neovascular AMD)
Product Composition
- Clone
- B20-4
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a humanized monoclonal antibody that inhibits angiogenesis by targeting vascular endothelial growth factor A (VEGF-A). VEGF-A is a signaling molecule that promotes the formation of new blood vessels, playing a significant role in various conditions, particularly cancer.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- VEGFA
- Full Name
- Vascular Endothelial Growth Factor A
- Sequence Similarities
- Belongs to the PDGF/VEGF growth factor family.
- Cellular Localization
- Secreted
- Protein Refseq
- NP_001020537.2; NP_001020538.2; NP_001020539.2
- Function
- Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H73 | Anti-Human VEGFA Recombinant Antibody (TAB-H73) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (TAB-009ML) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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