Human Anti-VEGFA Recombinant Antibody (clone XPA.10.064.10) (CAT#: HPAB-J0274-YC)
The affinity matured antibodies XPA.10.064.03, XPA.10.064.04, XPA.10.064.06, XPA.10.064.07, and XPA.10.064.10 as provided herein were generated by random mutagenesis of XPA.10.064 HCDR3 and subsequent binding and functional assays. The binding affinities of the affinity matured antibodies for hVEGF165 are greater than that of Bevacizumab.
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Inhib
Figure 1 Inhibition of hVEGF165 binding to VEGF-R1 by Bevacizumab (BM1), XPA.10.064, and XPA.10.072.
WB
Figure 2 Analysis of hVEGF-|65 epitopes bound by Bevacizumab (BM1), XPA.10.064 (064), and XPA.10.072 (072).
Neut
Figure 3 Inhibition of HUVEC proliferation by XPA.10.064 lgG2.
FuncS
Figure 4 Inhibition of A673 tumor growth in vivo by XPA.10.064.06.
Specifications
- Host Species
- Human
- Type
- Human IgG2
- Specificity
- Human VEGFA
- Species Reactivity
- Human, Mouse
- Clone
- XPA.10.064.10
- Applications
- Inhib, WB, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Functional Assay, Inhibition and Neutralization.
Target
- Alternative Names
- Vascular Endothelial Growth Factor A; Vascular Permeability Factor; VEGF; VPF; Vascular Endothelial Growth Factor A121; Vascular Endothelial Growth Factor A165; Vascular Endothelial Growth Factor; VEGF-A; MVCD1
- Gene ID
- 7422
- UniProt ID
- P15692
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kits & Antibodies
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Biparatopic Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H73 | Anti-Human VEGFA Recombinant Antibody (TAB-H73) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (TAB-009ML) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
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For Research Use Only. Not For Clinical Use.
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