BV421-DRB1*04:01/Human Tyrp1 (ISPNSVFSQWRVVCDSLEDYD) MHC Tetramer
CAT#: MHC-YF1461
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Tyrp1-derived peptide of ISPNSVFSQWRVVCDSLEDYD sequence covering 277-297 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
Normal Tissue
Figure 2 Skin
Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Tyrp1
- Antigen Species
- Human
- Peptide
- ISPNSVFSQWRVVCDSLEDYD
- Range
- 277-297
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
- Alternative Names
- TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
- Gene ID
- 7306
- UniProt ID
- P17643
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COA
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