PE-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer
CAT#: MHC-CN0102
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Normal Tissue
Figure 2 Fallopian tube
Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
❮
❯
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Mesothelin
- Antigen Species
- Human
- Peptide
- GQKMNAQAI
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
- Alternative Names
- MSLN; Pre-Pro-Megakaryocyte-Potentiating Factor; Mesothelin; MPF; SMRP; Megakaryocyte Potentiating Factor; CAK1 Antigen; Soluble MPF Mesothelin Related Protein
- Gene ID
- 10232
- UniProt ID
- Q13421
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Enhanced T Cell Detection
This MHC tetramer has greatly improved our flow cytometry assays, allowing detailed analysis of T cells targeting mesothelin. Its PE-conjugation provides vivid results, making it easier to analyze immune responses in cancer studies.
Reliable and Accurate Results
The accuracy delivered by this tetramer is impressive. It plays an integral role in our studies, consistently providing reliable data crucial for understanding T cell dynamics in tumor environments.
Q&As
-
What is the primary use of the MHC Tetramer featuring Human Mesothelin?
A: This MHC tetramer is primarily used for flow cytometry to detect antigen-specific T cells. It facilitates detailed examination of the immune response against Human Mesothelin, a cancer antigen, supporting cancer immunotherapy research.
-
How does the tetramer's PE-conjugation enhance its functionality?
A: PE-conjugation facilitates the visualization and quantification of antigen-specific T cells using flow cytometry, enhancing the detection sensitivity and accuracy of immune responses.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
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| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0392-YC) | ELISA, FC, IF | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (TAB-201) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-658 | Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009) | WB | Mouse IgG |
| HPAB-0861-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0861-CN) | ELISA, FC, Neut | Human IgG, λ |
| HPAB-1338-FY | Human Anti-MSLN Recombinant Antibody (HPAB-1338-FY) | ELISA, FC | Human IgG |
| HPAB-1339-FY | Human Anti-MSLN Recombinant Antibody (HPAB-1339-FY) | ELISA, FC | Human IgG |
| HPAB-1340-FY | Human Anti-MSLN Recombinant Antibody (HPAB-1340-FY) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL | Human Anti-MSLN Recombinant Antibody (TAB-0833CL) | ELISA, FuncS, Activ, FC | Human IgG1 |
| TAB-0834CL | Human Anti-MSLN Recombinant Antibody (TAB-0834CL) | ELISA, FuncS, FC, SPR, Inhib | Human IgG1, κ |
| TAB-0835CL | Human Anti-MSLN Recombinant Antibody (TAB-0835CL) | ELISA, FC, FACS, Inhib | Human IgG1, λ |
| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0834CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0834CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0041-CN-S(P)) | FC, WB, ELISA | Mouse scFv |
| HPAB-0042-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0042-CN-S(P)) | FC, WB, ELISA | Mouse scFv |
| HPAB-0043-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0043-CN-S(P)) | FC, WB, ELISA | Mouse scFv |
| HPAB-0045-CN-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0045-CN-S(P)) | FC, WB, ELISA | Human scFv |
| HPAB-0046-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0046-CN-S(P)) | FC, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0041-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0042-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0042-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0043-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0043-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0044-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0044-CN-F(E)) | FC, WB, ELISA | Human Fab |
| HPAB-0045-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0045-CN-F(E)) | FC, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0101 | APC-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer | FCM | |
| MHC-CN1049 | PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1050 | APC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-YF553 | A*01:01/Human Mesothelin (TLDTLTAFY) MHC Pentamer | FCM | |
| MHC-YF554 | A*02:01/Human Mesothelin (SLLFLLFSL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY69 | Human Anti-MSLN (clone SS) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC539 | Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4533 | Anti-MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4534 | Anti-Mouse MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4535 | Anti-Rat MSLN Immunohistochemistry Kit | IHC |
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