Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539)
CAT#: VS-0425-YC539
The Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MSLN-expressed cells or tissues. MSLN is predicted to play a role in cell-matrix adhesion and is expressed in structures such as the gut and respiratory system. It is implicated in diseases like ovarian and pancreatic cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Normal Tissue
Figure 2 Fallopian tube
Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MSLN
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Mesothelin
- Biological Process
- Cell adhesion
- Cellular Localization
- Vesicles, Plasma membrane
- Introduction
- Predicted to be involved in cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin).
- Alternative Names
- MPF
- Gene ID
- 56047
- UniProt ID
- Q61468
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0391-YC) | ELISA, FC, IF | Llama VHH |
| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0392-YC) | ELISA, FC, IF | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (TAB-201) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0833CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0834CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0834CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0835CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0835CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0834CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0834CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0041-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0042-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0042-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0043-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0043-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0044-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0044-CN) | FC, WB, ELISA | Human IgG |
| HPAB-0045-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0045-CN) | FC, WB, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0442LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0442LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| HPAB-0443LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0443LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| HPAB-0444LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0444LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| FAMAB-0257WJ-S(P) | Human Anti-MSLN Recombinant Antibody (clone H1a050); scFv Fragment | ELISA, WB, FC | Human scFv |
| FAMAB-0258WJ-S(P) | Human Anti-MSLN Recombinant Antibody (clone H1a064); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1049 | PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1050 | APC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1051 | FITC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1052 | A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1053 | PE-A*02:01/Human MSLN (SLLFLLFSL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1338-FY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-1338-FY-S(P)) | ELISA, FC | Human scFv |
| HPAB-1339-FY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-1339-FY-S(P)) | ELISA, FC | Human scFv |
| HPAB-1340-FY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-1340-FY-S(P)) | ELISA, FC | Human scFv |
| HPAB-1341-FY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-1341-FY-S(P)) | ELISA, FC | Human scFv |
| HPAB-1342-FY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-1342-FY-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY69 | Human Anti-MSLN (clone SS) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4533 | Anti-MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4534 | Anti-Mouse MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4535 | Anti-Rat MSLN Immunohistochemistry Kit | IHC |
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