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MSLN

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This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, IHC, FC, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
Mesothelin
Linker:
Cleavable, disulfide
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
MSLN
Linker:
protease-cleavable peptide linker
Drug:
MMAE (Monomethyl auristatin E)
Target:
mesothelin
Linker:
SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug:
DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
mesothelin
Target:
MSLN
Linker:
mc (maleimidocaproyl)
Drug:
MMAF (monomethyl auristatin F)
Target:
MSLN
Linker:
mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug:
MMAE (monomethyl auristatin E)
Target:
MSLN
Linker:
mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
Drug:
MMAF (monomethyl auristatin F)
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Species Reactivity:
Mouse
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
mesothelin
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Mouse
Cytokine 1 Species:
Human
Molecule Class:
IL12-scFv
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Human phage display library
Species Reactivity:
Mouse
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Mouse antibody
Application:
FC, IHC-Fr, WB
Species Reactivity:
Human
Type:
Mouse scFv
Application:
FC, WB, ELISA
Species Reactivity:
Human
Type:
Mouse scFv
Application:
FC, WB, ELISA
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