Human Anti-MSLN (clone SS) scFv-Fc Chimera
CAT#: VS-0325-FY69
Anti-MSLN (mesothelin) scFv-Fc (single-chain variable fragment-Fc) antibodies are a class of therapeutic antibodies designed to target and bind specifically to mesothelin, a glycoprotein that is overexpressed in various cancers, including mesothelioma, pancreatic cancer, and ovarian cancer. These antibodies are engineered for increased efficacy and stability, combining the specific binding capabilities of scFv fragments with the effector functions of an Fc domain from an immunoglobulin.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Normal Tissue
Figure 2 Fallopian tube
Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
❮
❯
Specifications
- Immunogen
- Full length mesothelin protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MSLN
- Species Reactivity
- Human
- Clone
- SS
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Mesothelin; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen; MPF; Soluble MPF Mesothelin Related Protein; Megakaryocyte Potentiating Factor; SMRP
- Gene ID
- 10232
- UniProt ID
- Q13421
- Long Name
- Mesothelin
- Sequence Similarities
- Belongs to the mesothelin family.
- Cellular Localization
- Cell membrane; Golgi apparatus; Membrane; Secreted
- Post Translation Modifications
- Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
- Protein Refseq
- NP_061345.1
- Function
- Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone SS"
- CAT
- Product Name
See other products for "MSLN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0391-YC) | ELISA, FC, IF | Llama VHH |
| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0392-YC) | ELISA, FC, IF | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (TAB-201) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0833CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0834CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0834CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0835CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0835CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
| TAB-0834CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0834CL-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0041-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0042-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0042-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0043-CN | Mouse Anti-MSLN Recombinant Antibody (HPAB-0043-CN) | FC, WB, ELISA | Mouse IgG |
| HPAB-0044-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0044-CN) | FC, WB, ELISA | Human IgG |
| HPAB-0045-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0045-CN) | FC, WB, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0041-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0042-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0042-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0043-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0043-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0044-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0044-CN-F(E)) | FC, WB, ELISA | Human Fab |
| HPAB-0045-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0045-CN-F(E)) | FC, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0706-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0706-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-0707-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0707-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-0708-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0708-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-1338-FY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-1338-FY-F(E)) | ELISA, FC | Human Fab |
| HPAB-1339-FY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-1339-FY-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1049 | PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1050 | APC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-CN1051 | FITC-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
| MHC-YF238 | A*02:01/Human Mesothelin (SLLFLLFSL) MHC Monomer | MHC Multimer | |
| MHC-YF239 | A*02:01/Human Mesothelin (VLPLTVAEV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC539 | Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4533 | Anti-MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4534 | Anti-Mouse MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4535 | Anti-Rat MSLN Immunohistochemistry Kit | IHC |
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