Human Anti-MSLN (clone SS) scFv-Fc Chimera

CAT#: VS-0325-FY69

Anti-MSLN (mesothelin) scFv-Fc (single-chain variable fragment-Fc) antibodies are a class of therapeutic antibodies designed to target and bind specifically to mesothelin, a glycoprotein that is overexpressed in various cancers, including mesothelioma, pancreatic cancer, and ovarian cancer. These antibodies are engineered for increased efficacy and stability, combining the specific binding capabilities of scFv fragments with the effector functions of an Fc domain from an immunoglobulin.

Gene Expression
Figure 1 IF staining of human cell line HeLa Figure 2 Fallopian tube Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)

Specifications

  • Immunogen
  • Full length mesothelin protein.
  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human MSLN
  • Species Reactivity
  • Human
  • Clone
  • SS
  • Applications
  • ELISA
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Mesothelin; Pre-Pro-Megakaryocyte-Potentiating Factor; CAK1 Antigen; MPF; Soluble MPF Mesothelin Related Protein; Megakaryocyte Potentiating Factor; SMRP
  • Long Name
  • Mesothelin
  • Sequence Similarities
  • Belongs to the mesothelin family.
  • Cellular Localization
  • Cell membrane; Golgi apparatus; Membrane; Secreted
  • Post Translation Modifications
  • Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Function
  • Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for VS-0325-FY69. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Isotype Control

Secondary Antibody

See other products for "Clone SS"

See other products for "MSLN"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
TAB-201 Anti-Human Mesothelin Recombinant Antibody (TAB-201) IP, IF, FuncS, FC, Neut, ELISA, IHC IgG1 - kappa
CAT Product Name Application Type
AGTO-G052E Anti-MSLN immunotoxin RG7787 (Fab)-PE Cytotoxicity assay, Function study
AGTO-G053E Anti-Msln immunotoxin (IgG)-PE Cytotoxicity assay, Function study
AGTO-L035E anti-MSLN immunotoxin K1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L063E anti-MSLN immunotoxin 8B35 (scFv)-PE Cytotoxicity assay, Functional assay
CAT Product Name Application Type
BRD-0376MZ Chicken Anti-MSLN Polyclonal IgY WB Chicken antibody
CAT Product Name Application Type
AFC-TAB-201 Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201) IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
CAT Product Name Application Type
VS-0425-YC539 Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539) ELISA, FC, Neut, Cell-uptake
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare