Human Anti-MSLN Recombinant Antibody (TAB-0834CL) (CAT#: TAB-0834CL)
Provided here is an isolated full human IgG1 antibody that binds to mesothelin. It was selected from a phage display library of human antibodies. This antibody can completely block the interaction of mesothelin and CA125 interaction on cancer cells. In addition, ELISA experiments have determined that it binds only human mesothelin but not mouse mesothelin.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Figure 2 Fallopian tube
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Human MSLN (Mesothelin)
- Species Reactivity
- Human
- Applications
- ELISA, FuncS, FC, SPR, Inhib
- Related Disease
- Ovarian cancer, lung cancer and pancreatic cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- See the COA
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor;
- Gene ID
- 10232
- UniProt ID
- Q13421
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1165z | Mouse Anti-MSLN Recombinant Antibody (clone 44C3) | WB, ELISA, IHC | Mouse IgG2a |
| HPAB-0442LY | Human Anti-MSLN Recombinant Antibody (HPAB-0442LY) | ELISA, FC, IHC, WB | Human IgG1 |
| HPAB-0443LY | Human Anti-MSLN Recombinant Antibody (HPAB-0443LY) | ELISA, FC, IHC, WB | Human IgG1 |
| HPAB-0444LY | Human Anti-MSLN Recombinant Antibody (HPAB-0444LY) | ELISA, FC, IHC, WB | Human IgG1 |
| HPAB-1338-FY | Human Anti-MSLN Recombinant Antibody (HPAB-1338-FY) | ELISA, FC | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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