Human Anti-CDH17 (clone D2101) scFv-Fc Chimera (CAT#: VS-0325-FY97)
The anti-CDH17 scFv-Fc antibody targets CDH17, a cell adhesion molecule involved in tissue development and homeostasis. It has potential therapeutic applications in diseases associated with CDH17 dysregulation, such as certain cancers and inflammatory disorders. The scFv-Fc format provides extended half-life and enhanced binding affinity, making it suitable for therapeutic use.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
Figure 2 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
Figure 3 Small intestine
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
Figure 4 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, OE19, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CDH17
- Species Reactivity
- Human
- Clone
- D2101
- Applications
- ELISA, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunohistochemistry: 5 µg/mL
Target
- Alternative Names
- Cadherin 17; Intestinal Peptide-Associated Transporter HPT-1; Cadherin 17, LI Cadherin (Liver-Intestine); Liver-Intestine Cadherin; Human Intestinal Peptide-Associated Transporter HPT-1; Human Peptide Transporter 1; HPT-1 Cadherin; Cadherin-16
- Gene ID
- 1015
- UniProt ID
- Q12864
- Long Name
- Cadherin 17
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn149, Asn184, Asn250, Asn419, Asn456, Asn546, Asn587, and Asn722
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites
- Protein Refseq
- NP_001138135.1; NP_001400880.1; NP_001400881.1; NP_001400882.1; NP_001400883.1
- Function
- LI-cadherin may have a role in the morphological organization of liver and intestine.
Involved in intestinal peptide transport.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2803z | Mouse Anti-CDH17 Recombinant Antibody (clone 23F8) | WB, ELISA, IHC | Mouse IgG1 |
| HPAB-M0033-YC | Mouse Anti-CDH17 Recombinant Antibody (HPAB-M0033-YC) | ELISA, FC, FuncS, IHC | Mouse IgG |
| HPAB-M0034-YC | Mouse Anti-CDH17 Recombinant Antibody (HPAB-M0034-YC) | ELISA, FC, FuncS, IHC | Mouse IgG |
| HPAB-M0035-YC | Human Anti-CDH17 Recombinant Antibody (HPAB-M0035-YC) | ELISA, FC, FuncS, IHC | Humanized IgG |
| HPAB-M0036-YC | Human Anti-CDH17 Recombinant Antibody (HPAB-M0036-YC) | ELISA, FC, FuncS, IHC | Humanized IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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