Human Anti-CDH17 (clone D2101) scFv-Fc Chimera
CAT#: VS-0325-FY97
The anti-CDH17 scFv-Fc antibody targets CDH17, a cell adhesion molecule involved in tissue development and homeostasis. It has potential therapeutic applications in diseases associated with CDH17 dysregulation, such as certain cancers and inflammatory disorders. The scFv-Fc format provides extended half-life and enhanced binding affinity, making it suitable for therapeutic use.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/1030_A11_3_selected.jpg
Normal Tissue
Figure 2 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23614/52777_A_9_2_val_selected.jpg
Normal Tissue
Figure 3 Small intestine
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Paneth cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_6_2.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23616/52785_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (CACO-2, OE19, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000079112-CDH17
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CDH17
- Species Reactivity
- Human
- Clone
- D2101
- Applications
- ELISA, Immunohistochemistry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunohistochemistry: 5 µg/mL
Target
- Alternative Names
- Cadherin 17; Intestinal Peptide-Associated Transporter HPT-1; Cadherin 17, LI Cadherin (Liver-Intestine); Liver-Intestine Cadherin; Human Intestinal Peptide-Associated Transporter HPT-1; Human Peptide Transporter 1; HPT-1 Cadherin; Cadherin-16
- Gene ID
- 1015
- UniProt ID
- Q12864
- Long Name
- Cadherin 17
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn149, Asn184, Asn250, Asn419, Asn456, Asn546, Asn587, and Asn722
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites
- Protein Refseq
- NP_001138135.1; NP_001400880.1; NP_001400881.1; NP_001400882.1; NP_001400883.1
- Function
- LI-cadherin may have a role in the morphological organization of liver and intestine.
Involved in intestinal peptide transport.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone D2101"
- CAT
- Product Name
See other products for "CDH17"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1415CL | Mouse Anti-CDH17 Recombinant Antibody (TAB-1415CL) | ELISA | Mouse IgG |
| TAB-1416CL | Mouse Anti-CDH17 Recombinant Antibody (TAB-1416CL) | ELISA | Mouse IgG |
| TAB-1417CL | Mouse Anti-CDH17 Recombinant Antibody (TAB-1417CL) | ELISA | Mouse IgG |
| TAB-1418CL | Mouse Anti-CDH17 Recombinant Antibody (TAB-1418CL) | FC | Mouse IgG |
| TAB-1419CL | Mouse Anti-CDH17 Recombinant Antibody (TAB-1419CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0112MZ | Chicken Anti-CDH17 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0617 | Hi-Affi™ Rabbit Anti-CDH17 Recombinant Antibody (clone DS617AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2061LY-F(E) | Human Anti-CDH17 Recombinant Antibody (clone D2101); Fab Fragment | ELISA | Human Fab |
| HPAB-M0033-YC-F(E) | Mouse Anti-CDH17 Recombinant Antibody; Fab Fragment (HPAB-M0033-YC-F(E)) | ELISA, FC, FuncS, IHC | Mouse Fab |
| HPAB-M0034-YC-F(E) | Mouse Anti-CDH17 Recombinant Antibody; Fab Fragment (HPAB-M0034-YC-F(E)) | ELISA, FC, FuncS, IHC | Mouse Fab |
| HPAB-M0035-YC-F(E) | Human Anti-CDH17 Recombinant Antibody; Fab Fragment (HPAB-M0035-YC-F(E)) | ELISA, FC, FuncS, IHC | Humanized Fab |
| HPAB-M0036-YC-F(E) | Human Anti-CDH17 Recombinant Antibody; Fab Fragment (HPAB-M0036-YC-F(E)) | ELISA, FC, FuncS, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2061LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2101); scFv Fragment | ELISA | Human scFv |
| HPAB-2062LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2111); scFv Fragment | ELISA | Human scFv |
| HPAB-2063LY-S(P) | Mouse Anti-CDH17 Recombinant Antibody (clone D2005); scFv Fragment | ELISA | Mouse scFv |
| HPAB-2064LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2008); scFv Fragment | ELISA | Human scFv |
| HPAB-2065LY-S(P) | Human Anti-CDH17 Recombinant Antibody (clone D2105); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0033-YC | Mouse Anti-CDH17 Recombinant Antibody (HPAB-M0033-YC) | ELISA, FC, FuncS, IHC | Mouse IgG |
| HPAB-M0034-YC | Mouse Anti-CDH17 Recombinant Antibody (HPAB-M0034-YC) | ELISA, FC, FuncS, IHC | Mouse IgG |
| HPAB-M0035-YC | Human Anti-CDH17 Recombinant Antibody (HPAB-M0035-YC) | ELISA, FC, FuncS, IHC | Humanized IgG |
| HPAB-M0036-YC | Human Anti-CDH17 Recombinant Antibody (HPAB-M0036-YC) | ELISA, FC, FuncS, IHC | Humanized IgG |
| VS3-QX207 | Mouse Anti-CDH17 Recombinant Antibody (clone D10-E1) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY392 | Anti-CDH17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1290 | Anti-Mouse CDH17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1289 | Anti-Human CDH17 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC250 | Recombinant Anti-CDH17 Vesicular Antibody, EV Displayed (VS-0425-YC250) | ELISA, FC, Cell-uptake |
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