Human Anti-CFD scFv-Fc Chimera (VS-0425-FY94) (CAT#: VS-0425-FY94)
This fusion protein targets CFD (Complement factor D), a critical component of the alternative complement pathway. By binding to CFD, it can modulate complement activation, with potential applications in treating autoimmune and inflammatory diseases where complement overactivity is implicated.
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RNA Expression
Figure 1 RNA cell line category: Group enriched (ASC diff, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197766-CFD
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197766-CFD
Specifications
- Immunogen
- Human CFD as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CFD
- Species Reactivity
- Human
- Applications
- Neutralization, ELISA
- Related Disease
- Age-related macular degeneration (AMD); including dry and wet (non-exudative and exudative) forms; choroidal neovascularization (CNV); uveitis; diabetic and other ischemia-related retinopathies; endophthalmitis; and other intraocular neovascular disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Complement Factor D; Properdin Factor D; Adipsin; D Component Of Complement (Adipsin); C3 Convertase Activator; EC 3.4.21.46; PFD
- Gene ID
- 1675
- UniProt ID
- P00746
- Long Name
- Complement Factor D
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Disulfide bond
Zymogen
- Protein Refseq
- NP_001304264.1; NP_001919.2
- Function
- Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-754 | Anti-CFD Recombinant Antibody (Lampalizumab) | ELISA, IP, FC, FuncS, Neut, IF | Fab - G1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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