SmartAb™ Recombinant Anti-CFD pH-dependent Antibody (VS-0825-YC79)
CAT#: VS-0825-YC79
The anti-CFD pH-dependent antibody (VS-0825-YC79) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human CFD. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for CFD under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from CFD at pH 6.0. This pH-sensitive antibody retains its binding affinity for CFD on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human CFD, also known as Factor D, is a serine protease that is a key component of the alternative pathway of the complement system. It cleaves factor B to initiate the cascade, playing a critical role in innate immunity.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (ASC diff, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197766-CFD
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Specifications
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- Human Fab (from IgG1 kappa)
- Specificity
- Human CFD
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, Neut, IF
Product Property
- Clonality
- Monoclonal
- Purification
- Protein L purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-754 | Anti-CFD Recombinant Antibody (Lampalizumab) | ELISA, IP, FC, FuncS, Neut, IF | Fab - G1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-034 | Recombinant Anti-CHRM2 VHH Single Domain Antibody (PNBL-034) | FACS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-646 | Human Anti-CFD Recombinant Antibody (clone mAb 166-32) | WB, IHC, IF, FuncS | Humanized IgG |
| PABC-140 | Human Anti-CFD Recombinant Antibody (clone AFD) | Neut | Human IgG |
| MOB-047CQ | Human Anti-CFD Recombinant Antibody (MOB-047CQ) | ELISA, IP, FC, FuncS, IF | Human IgG1, κ |
| HPAB-0147CQ | Human Anti-CFD Recombinant Antibody (HPAB-0147CQ) | ELISA, FC | Humanized IgG |
| HPAB-1074-FY | Mouse Anti-CFD Recombinant Antibody (HPAB-1074-FY) | ELISA, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-641 | Human Anti-CFD Recombinant Antibody (clone mAb 166-32); Fab Fragment | WB, IHC, IF, FuncS | Human Fab |
| HPAB-0147CQ-F(E) | Human Anti-CFD Recombinant Antibody; Fab Fragment (HPAB-0147CQ-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0148CQ-F(E) | Human Anti-CFD Recombinant Antibody Fab Fragment (HPAB-0148CQ-F(E)) | ELISA, FC, FuncS | Humanized Fab |
| HPAB-0325LY-F(E) | Human Anti-CFD Recombinant Antibody; Fab Fragment (HPAB-0325LY-F(E)) | Inhib | Human Fab |
| HPAB-0326LY-F(E) | Human Anti-CFD Recombinant Antibody; Fab Fragment (HPAB-0326LY-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-641 | Human Anti-CFD Recombinant Antibody (clone mAb 166-32); scFv Fragment | WB, IHC, IF, FuncS | Human scFv |
| HPAB-0749YY-S(P) | Human Anti-CFD Recombinant Antibody scFv Fragment (HPAB-0749YY-S(P)) | ELISA | Humanized scFv |
| HPAB-0750YY-S(P) | Human Anti-CFD Recombinant Antibody scFv Fragment (HPAB-0750YY-S(P)) | ELISA | Humanized scFv |
| HPAB-0751YY-S(P) | Human Anti-CFD Recombinant Antibody scFv Fragment (HPAB-0751YY-S(P)) | ELISA | Humanized scFv |
| HPAB-0752YY-S(P) | Human Anti-CFD Recombinant Antibody scFv Fragment (HPAB-0752YY-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4081 | Hi-Affi™ Rabbit Anti-CFD Recombinant Antibody (clone SI148DS) | WB | Rabbit IgG |
| MOR-4105 | Hi-Affi™ Rabbit Anti-CFD Recombinant Antibody (clone SI176DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY94 | Human Anti-CFD scFv-Fc Chimera (VS-0425-FY94) | Neut, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC57 | Recombinant Anti-CFD Eliminating Antibody, pH-Sensitive (VS-0625-YC57) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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