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CFD

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This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab - G1 - kappa
Application:
ELISA, IP, FC, FuncS, Neut, IF
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, Neut, FuncS
Species Reactivity:
Human
Type:
Human IgG1, κ
Application:
ELISA, IP, FC, FuncS, IF
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA, Inhib
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized scFv
Application:
ELISA, Inhib
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized Fab
Application:
ELISA, Inhib
Derivation:
Humanized
Species Reactivity:
Human
Type:
Human IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Human IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Human scFv
Application:
ELISA
Derivation:
Human
Species Reactivity:
Monkey
Type:
scFv
Application:
WB, IHC, IF, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Application:
I, E
Derivation:
Humanized
Species Reactivity:
Human
Application:
I, E
Species Reactivity:
Human
Application:
ELISA, IHC
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
ELISA
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