Human Anti-CSF2RA scFv-Fc Chimera (VS-0425-FY113) (CAT#: VS-0425-FY113)
This scFv-Fc construct targets CSF2RA (GM-CSF receptor alpha), a subunit of the receptor for GM-CSF. By modulating CSF2RA activity, it can influence immune cell function and has potential applications in inflammatory and autoimmune diseases.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human skin
(Immunohistochemical staining of human skin shows distinct cytoplasmic positivity in epidermal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/ihc_selected.jpg
(Immunohistochemical staining of human skin shows distinct cytoplasmic positivity in epidermal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_B_9_5.jpg
Figure 3 Colon
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_7_3.jpg
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_7_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_8_5.jpg
Figure 5 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_6_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_6_6.jpg
Figure 6 Placenta
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_3_7.jpg
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_3_7.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_9_8.jpg
Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198223-CSF2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198223-CSF2RA
Specifications
- Immunogen
- The immunogen is human CSF2RA/CD116.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human CSF2RA
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Colony Stimulating Factor 2 Receptor Alpha Subunit; Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage); Alpha-GM-CSF Receptor; GM-CSF-R-Alpha; CD116 Antigen; GMCSFR-Alpha; GMR-Alpha; CDw116; CSF2RY; CSF2R; Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha
- Gene ID
- 1438
- UniProt ID
- P15509
- Long Name
- Colony Stimulating Factor 2 Receptor Alpha Subunit
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylation at Asn135, Asn46, Asn182, Asn54, Asn195, Asn223, Asn229, Asn99, Asn123, Asn272, and Asn305
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 11 sites, 9 N-linked glycans (8 sites)
- Protein Refseq
- XP_011543922.1; XP_011543929.1; XP_011543930.1; XP_011544469.1; XP_011544476.1
- Function
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor.
Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L008D | GM-CSF-DT immunotoxin | Cytotoxicity assay, Functional assay |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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