Human Anti-CSF2RA scFv-Fc Chimera (VS-0425-FY113)
CAT#: VS-0425-FY113
This scFv-Fc construct targets CSF2RA (GM-CSF receptor alpha), a subunit of the receptor for GM-CSF. By modulating CSF2RA activity, it can influence immune cell function and has potential applications in inflammatory and autoimmune diseases.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skin
Immunohistochemical staining of human skin shows distinct cytoplasmic positivity in epidermal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_6_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_3_7.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16148/35783_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (BEWO, HMC-1, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198223-CSF2RA
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Specifications
- Immunogen
- The immunogen is human CSF2RA/CD116.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human CSF2RA
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Colony Stimulating Factor 2 Receptor Alpha Subunit; Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage); Alpha-GM-CSF Receptor; GM-CSF-R-Alpha; CD116 Antigen; GMCSFR-Alpha; GMR-Alpha; CDw116; CSF2RY; CSF2R; Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha
- Gene ID
- 1438
- UniProt ID
- P15509
- Long Name
- Colony Stimulating Factor 2 Receptor Alpha Subunit
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylation at Asn135, Asn46, Asn182, Asn54, Asn195, Asn223, Asn229, Asn99, Asn123, Asn272, and Asn305
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 11 sites, 9 N-linked glycans (8 sites)
- Protein Refseq
- XP_011543922.1; XP_011543929.1; XP_011543930.1; XP_011544469.1; XP_011544476.1
- Function
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor.
Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CSF2RA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2501z | Mouse Anti-CSF2RA Recombinant Antibody (clone 23G1) | WB, FC, IHC, IP | Mouse IgG1 |
| PABL-106 | Human Anti-CSF2RA Recombinant Antibody (PABL-106) | WB, Neut, FuncS | Human IgG |
| PABL-107 | Human Anti-CSF2RA Recombinant Antibody (PABL-107) | WB, Neut, FuncS | Human IgG |
| PABL-108 | Human Anti-CSF2RA Recombinant Antibody (PABL-108) | WB, Neut, FuncS | Human IgG |
| PABL-109 | Human Anti-CSF2RA Recombinant Antibody (PABL-109) | Neut, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L008D | GM-CSF-DT immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-106 | Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-106) | WB, Neut, FuncS | Human scFv |
| PSBL-107 | Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-107) | WB, Neut, FuncS | Human scFv |
| PSBL-108 | Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-108) | WB, Neut, FuncS | Human scFv |
| PSBL-109 | Human Anti-CSF2RA Recombinant Antibody; scFv Fragment (PSBL-109) | Neut, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-106 | Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-106) | WB, Neut, FuncS | Human Fab |
| PFBL-107 | Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-107) | WB, Neut, FuncS | Human Fab |
| PFBL-108 | Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-108) | WB, Neut, FuncS | Human Fab |
| PFBL-109 | Human Anti-CSF2RA Recombinant Antibody; Fab Fragment (PFBL-109) | Neut, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-533CQ | Rat Anti-Csf2ra Recombinant Antibody (clone CBL639) | FC, CyTOF®, ICC, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0826 | Hi-Affi™ Rabbit Anti-CSF2RA Recombinant Antibody (clone DS826AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC411 | Recombinant Anti-CSF2RA Vesicular Antibody, EV Displayed (VS-0425-YC411) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1708 | Anti-CSF2RA Immunohistochemistry Kit | IHC |
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